Publications by authors named "Hashimoto I"
Background/aim: The aim of the present study was to evaluate the clinical impact of the Global Immune-Nutrition-Information Index (GINI) in patients with esophageal cancer (EC) who received curative treatment and to clarify the potential of the GINI as a prognostic factor.
Patients And Methods: Patients who underwent curative resection for EC at Yokohama City University between 2000 and 2020 were consecutively chosen based on their medical records. The GINI was defined as follows: GINI=[C-reactive protein×platelet×monocyte×neutrophil]/[albumin×lymphocyte].
Background/aim: This study evaluated the clinical impact of anemia during the perioperative period on both short- and long-term oncological outcomes in resectable gastric cancer (GC) patients who received curative treatment.
Patients And Methods: We conducted a retrospective review of medical records and collected data from consecutive patients with gastric cancer who underwent curative resection at Yokohama City University between 2015 and 2022.
Results: A total of 330 patients were evaluated in this study.
Purpose: Reports on the association of perioperative nutritional and inflammatory status with the clinical course of adjuvant chemotherapy did not include neoadjuvant chemotherapy. We aimed to clarify the mechanism by which perioperative nutritional and inflammatory status affect the clinical course of postoperative adjuvant chemotherapy in patients with pancreatic cancer.
Methods: We enrolled 123 patients with pancreatic cancer retrospectively who underwent surgical resection with neoadjuvant and S-1 adjuvant chemotherapy between January 2013 and December 2022.
A 58-year-old man was treated with radical excision for rectal cancer. Pathological findings were pT3N1M0, Stage ⅢB, RAS: mutant, BRAF: mutant, MSS. The patient was followed up without adjuvant chemotherapy.
View Article and Find Full Text PDFBackground: This study aimed to determine the actual working conditions, including working hours and desired future working styles of hospital pediatricians and obstetricians/gynecologists (OB/GYNs) in Tokushima Prefecture.
Method: This cross-sectional study used a self-administered questionnaire. Pediatricians and OB/GYNs (n = 96) working at 14 hospitals in Tokushima Prefecture were surveyed.
Article Synopsis
- The study examines how short-term changes in skeletal muscle and adipose tissue after surgery affect survival and recurrence in gastric cancer patients.
- Patients were analyzed before and one month after surgery, categorizing them based on levels of muscle and fat loss.
- Results indicated that greater loss of adipose tissue correlated with lower survival rates, suggesting that monitoring adipose tissue changes post-surgery could help predict patient outcomes.
One risk factor for anastomotic leakage (AL) after esophagectomy with retrosternal gastric reconstruction is excessive compression of the gastric tube at the thoracic inlet. In this study, we evaluated the effect of our modified procedure to reduce AL by placing the esophagogastric anastomosis below the thoracic inlet. Between January 2008 and December 2022, 174 consecutive patients underwent subtotal esophagectomy with retrosternal gastric pull up, followed by circular stapler anastomosis in our hospitals.
View Article and Find Full Text PDFArticle Synopsis
- - Free jejunal transfer is an important surgical technique for reconstructing complex defects following total pharyngolaryngoesophagectomy (TPLE), especially when additional soft tissue removal is necessary. - The study presents a new approach using a combination of free jejunal and mesenteric flaps to simultaneously repair two distinct defects in a patient with extensive cancer-related tissue loss. - An 81-year-old patient successfully had a chimera flap surgery, leading to a smooth recovery without complications or recurrences for eight months, demonstrating the effectiveness of this dual reconstruction method.
Background/aim: We hypothesized that the inflammatory burden index (IBI) is a promising biomarker for esophageal cancer (EC) treatment and management. To confirm our hypothesis, we evaluated the prognostic impact of IBI in patients with EC who received curative treatment.
Patients And Methods: We conducted a retrospective review of medical records and collected data from consecutive patients with EC who underwent curative resection at Yokohama City University between 2005 and 2020.
Background/aim: Post-gastrectomy lean body mass (LBM) decrease has a significant negative impact on postoperative survival in patients with cancer. This study investigated the effect of intake of at least one-third of the daily protein requirement at breakfast on the maintenance of LBM in patients during the first month post-gastrectomy.
Patients And Methods: Among patients with gastric cancer who underwent curative distal gastrectomy between April 2011 and December 2018, without adjuvant chemotherapy, we evaluated 401 patients who had consumed more than the daily protein requirement in the first month postoperatively, using the FFQW82 nutrition intake questionnaire.
Article Synopsis
- The study investigates the systemic immune-inflammation index (SII) as a predictor of prognosis in patients with esophageal cancer who had curative surgery.
- Researchers analyzed data from 180 patients, classifying them into SII-high and SII-low groups based on a cutoff value of 500, finding significant differences in overall survival (OS) and recurrence-free survival (RFS) rates between the two groups.
- Results showed that a higher SII correlated with poorer survival outcomes and a greater chance of hematological recurrence, indicating that the SII could be a valuable marker for managing esophageal cancer.
Purpose: The C-reactive protein-albumin-lymphocyte (CALLY) index, which simultaneously evaluates the nutritional, immunological, and inflammatory statuses, is a new prognostic biomarker in patients with various cancers; however, no study has reported the clinical significance of the CALLY index in patients with pancreatic cancer. This study aimed to investigate whether the preoperative CALLY index is a prognostic biomarker in patients undergoing surgical resection of pancreatic cancer.
Methods: We retrospectively enrolled 461 patients with pancreatic cancer who underwent surgical resection between January 2013 and December 2022.
Article Synopsis
- * Out of 159 patients evaluated, over half experienced loss of skeletal muscle mass during neoadjuvant chemotherapy, which correlated with a significantly lower completion rate of S-1 adjuvant chemotherapy.
- * The findings suggest that addressing skeletal muscle loss during neoadjuvant chemotherapy could enhance the continuation of adjuvant treatment and potentially improve survival rates in these patients.
Article Synopsis
- Granzyme B (GZMB), produced by NK cells and CD8-positive T cells, plays a role in inducing apoptosis in tumor cells, and its expression was analyzed in gastric cancer (GC) patients post-surgery.
- A study involving 253 patients with pStage II/III GC showed significantly higher GZMB levels in tumor tissues compared to adjacent normal tissues, although it did not correlate with other clinicopathological features.
- The study found that patients with high GZMB expression had a better 5-year overall survival rate (72.0%) compared to those with low expression (55.7%), indicating that GZMB could serve as a valuable prognostic marker in advanced GC.
Article Synopsis
- The study investigates the role of hornerin (HRNR) protein in gastric cancer tissues of patients with advanced stages (II/III) who had surgery.
- HRNR levels were found to be significantly higher in cancerous tissues compared to normal tissues, with sex differences noted.
- Patients with high HRNR expression had a notably lower 5-year overall survival rate, indicating that HRNR could be a valuable prognostic marker for assessing outcomes in these cancer patients.
Article Synopsis
- A study was conducted on 37 patients to evaluate a new method for lower eyelid reconstruction using skin flaps to address issues like flap drooping.
- Patients were divided into two groups; Group A used traditional reconstruction techniques, while Group B employed a novel approach combining a periosteal flap and a de-epithelialized triangular flap.
- Results showed that Group B had significantly better outcomes in terms of drooping index, canthal tilt, and patient satisfaction compared to Group A, indicating the new method is more effective.
Background: Chylothorax, a rare but serious complication following esophagectomy, can lead to dehydration, malnutrition, and even mortality. Surgical intervention is considered when conservative treatment is ineffective; however, in some refractory cases, the cause of chylothorax remains unclear. We report a case of refractory chylothorax caused by abdominal chyle leakage into the pleural space via an unenclosed esophageal hiatus.
View Article and Find Full Text PDFGastric cancer (GC) is the fifth most common cancer and fourth leading cause of cancer-related deaths worldwide. Gastrectomy with lymphadenectomy is the standard treatment for both early and locally advanced GC. Laparoscopic surgery has been widely used for decades for the treatment of benign diseases, such as cholecystectomy and appendectomy.
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- The study assessed the Inflammatory Burden Index (IBI) as a potential prognostic marker for gastric cancer (GC) patients undergoing gastrectomy, highlighting its relationship with patient outcomes.
- Researchers analyzed data from 459 patients treated at the Kanagawa Cancer Center, finding that those with a high IBI had lower overall survival and recurrence-free survival rates compared to those with a low IBI.
- The findings suggest that a high preoperative IBI is an independent predictor of poor prognosis, indicating its potential utility in clinical decision-making for GC treatment.
Background/aim: We hypothesized that the hemoglobin, albumin, lymphocyte, and platelet (HALP) score may be a promising marker for the treatment and management of gastric cancer (GC). To test this hypothesis, we evaluated the clinical impact of the HALP score in patients with GC who received curative treatment.
Patients And Methods: Consecutive patients who underwent curative resection for GC at the Yokohama City University between 2005 and 2020 were selected based on their medical records.
The association of computed tomography (CT)-derived skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) with postoperative prognosis in patients with gastric cancer (GC) remains unknown. Therefore, the present study aimed to assess the association between SMI and SMD with 5-year overall survival (OS) and recurrence-free survival (RFS) in patients with GC. SMI and SMD were measured preoperatively in patients who underwent gastrectomy.
View Article and Find Full Text PDFBackground/aim: The sex-specific effect of the visceral-to-subcutaneous fat ratio (VSR) before gastrectomy on postoperative survival in patients with gastric cancer (GC) remains unclear. This study measured the preoperative VSR in patients with GC and analyzed its relationship with 5-year overall survival (OS) and relapse-free survival (RFS) by sex.
Patients And Methods: This prospective study included 540 patients with GC undergoing gastrectomy.
Background/aim: The aim of the present study was to evaluate the clinical impact of the Global Immune-Nutrition-Information Index (GINI) in patients with gastric cancer (GC) who received curative treatment and to clarify the potential of the GINI as a biomarker.
Patients And Methods: Patients who underwent curative resection for GC at Yokohama City University between 2005 and 2020 were selected based on their medical records. The GINI was calculated as follows: GINI=[C-reactive protein × platelet × monocyte × neutrophil]/[albumin × lymphocyte].
Article Synopsis
- The study examined postoperative dietary intake differences between men and women after surgery for early gastric cancer.
- Participants had their dietary intake assessed before surgery and one and three months after, revealing significant differences in caloric intake between the sexes at these intervals.
- While the rate of dietary intake loss was similar for both genders after surgery, the overall dietary intake levels were significantly different, suggesting the need for tailored nutritional support post-surgery.
Background/aim: Systemic immune-inflammation index (SII) was developed and evaluated for various malignancies. This study evaluated the clinical impact of the SII in patients with gastric cancer (GC) who received curative treatment.
Patients And Methods: Patients who underwent curative resection for GC at Yokohama City University between 2005 and 2020 were chosen consecutively based on their medical records.