Real-world clinical results of CGRP monoclonal antibody treatment for medication overuse headache of migraine without abrupt drug discontinuation and no hospitalization.

Background: Abrupt discontinuation of overused medications is standard treatment for medication overuse headache (MOH), but discontinuation is difficult to maintain. The aim was to evaluate the real-world clinical results of anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) treatment for migraine with MOH without abrupt drug discontinuation and no hospitalization.

Methods: Data were collected before starting CGRP-mAb injections (baseline) and 1 month after each injection.

Evaluation of mild cognitive impairment in older patients with essential tremor.

Introduction: Recent studies have reported that essential tremor (ET) presents with not only motor symptoms but also cognitive dysfunction. However, detailed pathological mechanisms remain unclear. Here, we evaluate the characteristics of cognitive changes in older patients.

[Development of Image Database for Kiken-yochi Training (KYT) in Radiology Practice].

Kiken-yochi Training (KYT) has been introduced in many hospitals as medical safety education in many departments, with the exception of radiology. KYT is also not used in the contents of medical safety lectures in the education of students for radiological technologists. One of the reasons for this is that the images for KYT (KYT images) cannot be created at each hospital or easily obtained on the website.

[Development of Dose Calculation Application for Computed Tomography Dose Management When Facility Protocols Differ from Diagnostic Reference Level (DRL)].

Purpose: In this study, we aimed to develop an application that computes dose values resembling diagnostic reference level (DRL) conditions when disparity prevents direct dose comparisons between the national diagnostic reference levels in Japan 2020 (Japan DRLs_2020) and facility-specific computed tomography (CT) protocols.

Methods: We developed an application using the R programming language and RStudio software that computes dose values and median values based on Japan DRLs_2020 imaging conditions following extraction of necessary information for dose calculations from the Radiation Dose Structured Report (RDSR) and Digital Imaging and Communications in Medicine (DICOM) tags. To ensure a user-friendly experience, we used the Shiny package to develop a graphical user interface that enables the application to operate seamlessly in web browsers.

Outcomes and Prognostic Factors of Magnetic Resonance-guided Focused Ultrasound Thalamotomy for Essential Tremor at 2-year Follow-up.

Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an effective treatment for essential tremor (ET). However, its long-term outcomes and prognostic factors remain unclear. This study aimed to retrospectively investigate 38 patients with ET who underwent MRgFUS thalamotomy and were followed up for >2 years.

Boltless nylon-suture technique for stereotactic electroencephalography as a safe, effective alternative when the anchor bolt is inappropriate.

Background: The use of anchor bolts to secure electrodes to the skull can be difficult in some clinical situations. Herein, we present the boltless technique to secure electrodes to the scalp using nylon sutures to overcome the problems associated with anchor bolts. We investigated the safety, accuracy errors, and patient-related and operative factors affecting errors in the boltless technique.

Characteristics of deceased subjects transported to a postmortem imaging center due to unusual death related to epilepsy.

Objective: Patients with epilepsy have high risk of experiencing uncommon causes of death. This study aimed to evaluate patients who underwent unusual deaths related to epilepsy and identify factors that may contribute to these deaths and may also include sudden unexpected death in epilepsy (SUDEP).

Methods: We analyzed 5291 cases in which a postmortem imaging (PMI) study was performed using plane CT, because of an unexplained death.

α-Tocopherol Depletion Exacerbates Lipopolysaccharide-Induced Reduction of Grip Strength.

Background: α-Tocopherol (αT) deficiency causes several neurologic disorders, such as spinocerebellar ataxia, peripheral neuropathy, and myopathy. Furthermore, decreased antibody production, impaired ex vivo T cell function, and elevated cytokine production are observed in humans and mice with αT deficiency. Although modeling αT deficiency in animals is challenging, αT depletion can be more readily achieved in α-tocopherol transfer protein-null (Ttpa) mice than wild-type (WT) mice.

α-Tocopherol Transfer Protein-Null Mice with Very Low α-Tocopherol Status Do Not Have an Enhanced Lipopolysaccharide-Induced Acute Inflammatory Response.

Background: The α-tocopherol transfer protein-null () mouse model is a valuable tool for studying the molecular and functional consequences of vitamin E (α-tocopherol, αT) deficiency. Because αT has been associated with reduced oxidative stress and improved immune function, we hypothesized that depleted αT concentration would exacerbate LPS-induced acute inflammatory response in the brain and heart of mice fed a vitamin E deficient (VED) diet.

Objectives: The objective was to investigate how extremely low αT status, followed by exposure to LPS, altered the acute inflammatory response to LPS in and wild-type () mice.

Crystallinity in periodic nanostructure surface on Si substrates induced by near- and mid-infrared femtosecond laser irradiation.

Laser-induced periodic surface structure (LIPSS), which has a period smaller than the laser wavelength, is expected to become a potential technique for fine surface processing. We report the microscopic and macroscopic observations of the crystallinity of LIPSSs, where the characteristics such as defects generation and residual strain were analyzed, respectively. The LIPSSs were formed on a Si substrate using two different femtosecond pulses from Ti:Sapphire laser with near-infrared wavelength (0.

Spontaneous regression of asymptomatic tumefactive perivascular spaces in the anterior temporal lobe.

Perivascular spaces are fluid-filled spaces that surround the perforating vessels of the brain and are normal findings on brain imaging. These are usually asymptomatic and are considered a manifestation of aging. Perivascular spaces occasionally undergo significant enlargement and are referred to as tumefactive perivascular spaces, which are often indistinguishable from neoplastic lesions.

Uniformity evaluation of laser-induced periodic surface structures formed by two-color double-pulse femtosecond laser irradiation.

The Perpendicular Period and Phase Scanning (PS) method can evaluate the uniformity of a laser-induced periodic surface structure (LIPSS). PS assesses the uniformity of LIPSS using the standard deviation of the peak period and the average of the phase difference in the direction perpendicular to LIPSS. The PS method demonstrates that LIPSS formed by two-color double-pulse irradiation is reduced to a quarter of the period dispersion, and the average phase difference of LIPSS is also reduced compared to the single-pulse irradiation.

CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis.

Drug-induced liver injury (DILI) is the main cause of failure in drug development and postapproval withdrawal. Although toxicogenomic techniques provide an unprecedented opportunity for mechanistic assessment and biomarker discovery, they are not suitable for the screening of large numbers of exploratory compounds in early drug discovery. Using a comprehensive analysis of toxicogenomics (TGx) data, we aimed to find DILI-relevant transcription factors (TFs) that could be incorporated into a reporter gene assay system.

Advocation and advancements of EPR effect theory in drug delivery science: A commentary.

To honor the contributions of Professor Hiroshi Maeda to the progress of targeted drug delivery research, a brief review of enhanced permeability and retention (EPR) effect theory proposed by him as the physiology-based principal mechanism of intra-tumoral accumulation of large molecules and small particles is presented. Under historical and practical backgrounds in developments of various drug delivery systems including macromolecular conjugates, the concept of EPR effect was advocated in mid1980s and has cultivated new cancer chemotherapeutic modalities until recently. Namely, nanoplatforms such as polymer conjugates, liposomes, polymeric micelles, and nanoparticles have been studied as a promising fusion area for nanotechnology and medicine.

Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells.

Mitochondrial calcium homeostasis plays critical roles in cell survival and aerobic metabolism in eukaryotes. The calcium uniporter is a highly selective calcium ion channel consisting of several subunits. Mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) are core subunits of the calcium uniporter required for calcium uptake activity in the mitochondria.

Minocycline Hydrochloride Controlled-release Microsphere Preparation Process Optimization Based on the Robust Design Method.

Objectives: The objective of the present study is to establish a robust preparation method that could steadily produce minocycline hydrochloride (MCH) microspheres regardless of used polymer types.

Materials And Methods: Taguchi's Robust Experimental Design methodology was employed to optimize the process parameters for MCH-loaded poly(D,L-lactide-co-glycolide) (PLGA) microspheres. In the experimental design, seven controllable factors, i.

[Prediction of the Incomplete Region of Fat Suppression Using the Banding Artifact of the Balanced Steady-state Free Precession Sequence].

When the fat-suppression technique was used in the MRI examinations of neck and extremities, incomplete regions of fat suppression were depicted frequently. These incomplete regions were caused by the non-uniform static magnetic field (B). On the other hand, a non-uniform B caused banding artifacts using a balanced steady-state free precession (bSSFP) sequence.

Accuracy of the Barrett Universal II formula integrated into a commercially available optical biometer when using a preloaded single-piece intraocular lens.

Purpose: To compare the commonly used formulas for intraocular lens (IOL) selection using IOLMaster700 (Carl Zeiss Meditec) and to evaluate the Barrett Universal II (BU-II) formula accuracy when using the Vivinex™ iSert XY1 IOL (Hoya Corporation Medical Division).

Methods: A retrospective chart review was performed that included patients who underwent uneventful cataract surgery with in-the-bag insertion of Vivinex™ iSert XY1 IOL. Prediction errors at 3 months postoperative of IOLMaster 700 with Haigis, Holladay 1, SRK/T, and BU-II formulas were compared.

Absolute response of a Fuji BAS-TR imaging plate to low-energy protons (<0.2 MeV) and carbon ions (<1 MeV).

This paper reports on the absolute response of a Fuji BAS-TR image plate to relatively low-energy protons (<0.2 MeV) and carbon ions (<1 MeV) accelerated by a 10-TW-class compact high-intensity laser system. A Thomson parabola spectrometer was used to discriminate between different ion species while dispersing the ions according to their kinetic energy.