Publications by authors named "Hashem H Ghoraba"
Purpose: This study compared two imaging grading techniques to assess the utility of longitudinal image-based analysis in retinopathy of prematurity (ROP) screening: (1) time-limited without image comparison (a proxy for bedside indirect ophthalmoscopy, termed sBIO) and time-unlimited with image comparison (for telemedicine grading, termed TELE) screening. We tested two hypotheses: (1) H1: TELE was superior to sBIO for the detection of change (Tempo)-same, better, or worse and (2) H2: granular data of change (e.g.
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- - The study aimed to analyze risk factors for developing anti-adalimumab antibodies (AAA) in patients with non-infectious uveitis undergoing treatment with adalimumab, using a retrospective case-control method.
- - Out of 31 patients, those who tested positive for AAA had significant differences compared to those who tested negative, particularly concerning gender, systemic disease presence, and baseline inflammation. Notably, interruptions in anti-TNF therapy and disease flare-ups during treatment increased the likelihood of developing AAA.
- - Conversely, patients receiving weekly doses of adalimumab showed a lower risk of developing AAA, indicating that treatment frequency could play a role in patient management for those at higher risk.
Article Synopsis
- * The article reviews the use of anti-TNF-α agents in treating NIU, noting their success in improving patient outcomes, while also addressing obstacles in further research and drug development in this area.
- * Despite the effectiveness of existing anti-TNF-α medications like infliximab and adalimumab, the future of developing new options in this category may be limited due to expiring patents and competition from biosimilars and other novel treatments.
Article Synopsis
- A 57-year-old diabetic man initially diagnosed with coccidioidomycosis (CI) presented with vision problems in his left eye, leading to an MRI and other tests that showed signs of neurosarcoidosis instead.* -
- Despite starting antifungal therapy that provided minimal improvement, further biopsy and PET CT asserted the diagnosis of sarcoidosis, prompting a treatment shift to prednisone and later infliximab, effectively managing his symptoms.* -
- This case highlights the importance of accurate differential diagnosis, as symptoms of neurosarcoidosis can mimic those of other conditions like coccidioidomycosis, impacting treatment decisions.*
Ocular Ischemic Syndrome in the Setting of Normal Carotid Duplex Ultrasound.
Retin Cases Brief Rep
December 2023
Article Synopsis
- - The study reports two cases of ocular ischemic syndrome (OIS) that were overlooked due to negative carotid duplex ultrasound (DUS) results, but later confirmed through angiography.
- - In the first case, a 67-year-old woman was misdiagnosed with retinal vasculitis but showed severe stenosis in the aortic arch after further imaging, leading to successful treatment that resolved her symptoms.
- - The second case involved a 41-year-old man with systematic vasculitis, where delayed retinal perfusion was detected despite a negative DUS, and MRA confirmed stenosis in the ophthalmic artery.
Rapid Improvement in Lipid Maculopathy Following Faricimab Therapy in Recalcitrant Familial Exudative Vitreoretinopathy.
Ophthalmic Surg Lasers Imaging Retina
July 2023
A monocular 22-year-old man with recalcitrant familial exudative vitreoretinopathy presented with progressive subretinal lipid exudation and lipid maculopathy that responded poorly to repeated aflibercept injections. The subretinal exudation started temporally and gradually progressed, involving the macula and the retinal periphery in all 4 quadrants. At the 22-month follow-up visit, macular and peripheral subretinal exudation persisted despite a total of 29 injections.
View Article and Find Full Text PDFPurpose: To report different biometric measurements in high myopia associated with different underlying ocular and genetic conditions.
Design: Retrospective study.
Subjects: Patients with high myopia.
Purpose: This is a retrospective case report in which we describe our findings in two cases of endophthalmitis associated with perforating gunshot injury, in which we documented intraocular intrusion of multiple eyelashes as a plausible source of infection.
Patients And Methods: Two male patients, 22 and 29 years old, respectively, presented with endophthalmitis following primary repair of rupture globe secondary to gunshot injury. Both patients had vitrectomy and silicone oil injection.
Purpose: To report a novel finding of retinal arterial tortuosity (RAT) associated with Ehlers-Danlos syndromes (EDS).
Methods: We queried the STAnford Research Repository (STARR) database to identify patients diagnosed with EDS. We included patients with a confirmed diagnosis of any subtype of EDS who had any form of readable retinal imaging including colour fundus photos, autofluorescence, red-free photos, red-free optical coherence tomography photos and fluorescein angiography.
Unprompted Closure of Spontaneous Macular Hole Secondary to Retained Subfoveal Perfluorocarbon Liquid.
Case Rep Ophthalmol Med
September 2022
Purpose: To report unprompted closure of spontaneous macular hole secondary to inadvertent subfoveal perfluorocarbon liquid (PFCL) after vitrectomy surgery. . We present a case of a retained large single subfoveal PFCL droplet following vitrectomy and silicone oil injection for subtotal rhegmatogenous retinal detachment that showed spontaneous release 3 weeks postoperatively, with subsequent development of full thickness macular hole (FTMH) which completely closed later on after silicone oil removal without internal limiting membrane peeling with marvelous anatomic and visual improvement after spontaneous closure of MH.
View Article and Find Full Text PDFAim: To describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).
Methods: Medical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included.
Port Delivery System With Ranibizumab: As Always - Risks Versus Benefits for the Recipients.
Ophthalmic Surg Lasers Imaging Retina
August 2022
Gene therapy has emerged as a research topic of choice in recent years. The eye in particular is one of few organs of the body for which gene therapy has received Food and Drug Administration approval, and it remains a field of great interest for gene therapy development. However, its associated immune and inflammatory reactions may render the treatment ineffective or harmful, which are of particular concern for the eyes due to their susceptibility to inflammation.
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- This study assessed the safety of high-dose pulse intravenous methylprednisolone (IVHDM) for treating severe pediatric uveitis, analyzing patients aged 16 and younger who received doses of at least 500 mg over several months.
- Out of twenty patients identified, 14 received IVHDM long-term, showing a mean age of 11.9 years, and half were female; various adverse events (AEs) were reported, including bradycardia and adrenal insufficiency.
- The study concluded that while IVHDM could be an effective treatment for tough cases of pediatric uveitis, adverse events may be linked to other immunomodulatory therapies or the disease itself, not solely to the IVHDM treatment
Purpose: To compare different types of macular holes regarding the anatomic and functional success following pars plana vitrectomy (PPV) and internal limiting membrane (ILM) removal.
Methods: A retrospective review of all patients with macular holes treated by PPV, ILM removal with gas tamponade from January 2014 to July 2017 in Magrabi Eye Hospital.
Results: One hundred fifty-seven eyes of 153 patients were analyzed.
Purpose: To report the long-term follow-up of patients with inadvertent retained submacular perfluorocarbon liquid (PFCL) bubbles after vitrectomy surgery.
Background: PFCL has unique chemical and physical features which facilitate displacement of subretinal fluid from central toward periphery allowing intraoperative reattachment of the mobile retina and manipulation of the anterior part of the detached retina without performing drainage retinotomy. Despite these advantages, PFCL droplets may be inadvertently retained in the submacular space.
Safety of high-dose intravitreal triamcinolone acetonide as low-cost alternative to anti-vascular endothelial growth factor agents in lower-middle-income countries.
Clin Ophthalmol
November 2018
Purpose: The purpose of this study was to evaluate the safety of high-dose intravitreal triamcinolone acetonide (IVTA) as affordable low-cost alternative to anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [anti-VEGF] agents) in lower-middle-income countries.
Patients And Methods: This was a retrospective interventional non-comparative case series. The study recruited patients who received 20 mg IVTA for treating various retinal and optic nerve diseases over the past 5 years.