TRIM37 interacts with PTEN to promote the growth of human T-cell acute lymphocytic leukemia cells through regulating PI3K/AKT pathway.

Background: TRIM37 has been reported to be associated with the tumorigenesis of cancers. However, the role of TRIM37 in T-cell acute lymphoblastic leukemia (T-ALL) remains unclear. This study aimed to characterize the effect of TRIM37 on T-ALL.

THBS2 promotes cell migration and invasion in colorectal cancer via modulating Wnt/β-catenin signaling pathway.

Colorectal cancer (CRC) is the most common human digestive malignancy with a poor prognosis; the pathophysiology of colon cancer involves multiple linkages of regulatory networks. Recently, thrombospondin 2 (THBS2) has been extensively studied for its role in cancer progression. In this study, we evaluated the expression of THBS2 in CRC tissues and studied the possible mechanism by which THBS2 regulates CRC progression.

[Trends of overweight and obesity in aged 7 to 18 Mongolian ethnic children and adolescents from 1985-2010].

Objective: To study the overweight and obesity situation among Mongolian ethnic children and adolescents in the last 25 years and to provide a basis on related prevention and control measures.

Methods: A cross-sectional study was used, with 18 366 aged 7 to 18 Mongolian ethnic children and adolescents involved. Surveys on their physical health, in 1985, 2000 and 2010 were carried out.

[Investigation on Borrelia burgdorferi sensu lato in ticks and rodents collected in Da Xing-An Mountains Forest areas of China].

Objective: To detect and study the types of Borrelia burgdorferi sensu lato in ticks and rodents from Da Xing-An Mountains Forest areas of China.

Methods: Nested PCR was performed to amplify 5S-23S rRNA intergenic spacer of B. burgdorferi.