Metformin efficacy and safety as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled trial.

Background: Antidiabetic medications have shown efficacy in alleviating autism symptoms. However, there is a lack of clinical research on the impact of metformin on irritability associated with autism. This study aimed to assess the efficacy and safety of metformin as an adjuvant therapy with risperidone for managing irritability in children diagnosed with Autism Spectrum Disorder (ASD).

A biocompatible cellulose gum based CMC/PVA/SBA-15 film as a colloidal antibacterial agent against MRSA.

The development of biocompatible antibacterial films plays a crucial role in the fight against antibiotic-resistant bacteria strains. Here, we developed an SBA-15-NH decorated biocompatible CMC/PVA film containing Ag NPs as an antibacterial material against Gram-positive and Gram-negative bacteria strains. The structure of the manufactured film was studied by XRD, SEM, mapping, and TGA analysis showing its formation and firm structure.

The functional roles of competitive endogenous RNA (ceRNA) networks in apoptosis in human cancers: The circRNA/miRNA/mRNA regulatory axis and cell signaling pathways.

Circular RNAs are noncoding RNAs with circular conformation mainly due to backsplicing event. CircRNAs can potentially impact cell biological processes by interacting with cell signaling pathways. Numerous circRNAs have been found to be aberrantly expressed in a variety of cancers.

Optimization of carbon emission in an integrated machine-piece scheduling and vehicle routing problem and its solution using MOPSO and NSGAII metaheuristic algorithms.

The growth of the global economy is accompanied by significant energy consumption, and greenhouse gas emissions create various problems such as global warming and environmental degradation. To protect the environment, governments are seeking to reduce carbon emissions. Production systems that operate solely based on economic factors in the workshop only consider problems such as production speed, cost, and processing time.

Bactericidal behavior of silver nanoparticle decorated nano-sized magnetic hydroxyapatite.

Methicillin-resistant (MRSA) is the most common cause of acute bacterial arthritis. Due to the increase in antibiotic resistance in these bacteria, the discovery of new antibacterial agents has become one of the hot topics in the scientific community. Here, we prepared a nano-sized porous biocompatible magnetic hydroxyapatite through a solvothermal method.

Exploring the Association of Serum Uric Acid Levels with Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis.

The role of uric acid in pathogenesis of benign paroxysmal positional vertigo (BPPV) is not fully understood. It is aimed to assess the serum uric acid levels in BPPV patients compared to healthy controls. Systematic review and meta-analysis.

Survival Factors in 1580 Adults with Spinal Ependymoma: Insights from a Multicenter Oncology Database.

Background: Using a multi-institutional oncology database, we investigate the survival rates and the impacts of demographic, clinical, and management characteristics on overall survival among adult patients diagnosed with spinal ependymoma.

Methods: Utilizing the SEER registry, patients with histologically or radiologically confirmed ependymomas were included. Factors impacting overall survival were analyzed using Kaplan-Meier survival curves and log-rank statistical analyses.

Green stabilization of silver nanoparticles over the surface of biocompatible FeO@CMC for bactericidal applications.

The emergence of antimicrobial resistance in bacteria, especially in agents associated with urinary tract infections (UTIs), has initiated an exciting effort to develop biocompatible nanoparticles to confront their threat. Designing simple, cheap, biocompatible, and efficient nanomaterials as bactericidal agents seems to be a judicious response to this problem. Here, a solvothermal method was hired for the one-pot preparation of the cellulose gum (carboxymethyl cellulose, CMC) magnetic composite to prepare a cost-effective, efficient, and biocompatible support for the plant-based stabilization of the silver NPs.

The Influence of Three-Dimensionally Printed Polymer Materials as Trusses and Shell Structures on the Mechanical Properties and Load-Bearing Capacity of Reinforced Concrete.

Three-dimensional printing technology (3D printing) is becoming a more and more popular technology for aerospace, biology, medicine, mechanics, civil and other engineering fields. In civil engineering, researchers and engineers attempt to print construction materials such as concrete using 3D-printing technology. This study aims to investigate the reinforcement of concrete beams with 3D printing.

Effects of cinnamon on anthropometric indices and headache-related disability of patients with migraine: A randomized double-blind placebo-controlled trial.

Objective: Increased body mass index (BMI) seems to be a risk factor for migraine attacks. Cinnamon has anti-inflammatory, neuroprotective, and anti-obesity effects. This study aimed to assess the effects of cinnamon on anthropometric indices and headache-related disability of patients with migraine.

Design of a sustainable supply chain network of biomass renewable energy in the case of disruption.

Non-renewable energy sources, including fossil fuels, are a type of energy whose consumption rate far exceeds its natural production rate. Therefore, non-renewable resources will be exhausted if alternative energy is not fully developed, leading to an energy crisis in the near future. In this paper, a mathematical model has been proposed for the design of the biomass supply chain of field residues that includes several fields where residue is transferred to hubs after collecting the residue in the hub, the residue is transferred to reactors.

The Association of Dietary Inflammatory Index and Cognitive Function in Iranian Elders.

Background: Cognitive impairment is amongst the most substantial mental health problems in elderly people, and inflammation is an underlying mechanism for cognitive impairment. The dietary inflammatory index (DII®) reflects the overall inflammatory potential of individuals' diets. The current study aimed to assess the relationship between the DII and cognitive function among the Iranian old population.

Nucleic acid-responsive smart systems for controlled cargo delivery.

Stimulus-responsive delivery systems allow controlled, highly regulated, and efficient delivery of various cargos while minimizing side effects. Owing to the unique properties of nucleic acids, including the ability to adopt complex structures by base pairing, their easy synthesis, high specificity, shape memory, and configurability, they have been employed in autonomous molecular motors, logic circuits, reconfigurable nanoplatforms, and catalytic amplifiers. Moreover, the development of nucleic acid (NA)-responsive intelligent delivery vehicles is a rapidly growing field.

The effect of an educational program on illness uncertainty in mothers of children with type 1 diabetes: a quasi-experimental study.

The mother is traditionally the primary caregiver for the child, and uncertainty is a major source of psychological distress for parents of sick children. As a result, the current study sought to investigate the impact of an educational program on illness uncertainty in mothers of children with insulin-dependent diabetes mellitus (IDDM). This is a quasi-experimental study with a pretest-posttest design, involving 40 mothers of children with IDDM.

Comparing Sequential Organ Failure Assessment Score, Acute Physiology and Chronic Health Evaluation II, Modified Acute Physiology and Chronic Health Evaluation II, Simplified Acute Physiology Score II and Poisoning Severity Score for Outcome Prediction of Pesticide Poisoned Patients Admitted to the Intensive Care Unit.

Objective: This study aimed to assess the severity of poisoning, various scoring systems, including Sequential Organ Failure Assessment (SOFA) score, acute physiology and chronic health evaluation II (APACHE II), Simplified Acute Physiology Score (SAPS II), Modified APACHE II, and poisoning severity score (PSS) were used. In this study, we compared the predictive value of these scoring systems on the outcome of pesticide-poisoned patients.

Methods: This is a cross-sectional study of pesticide-poisoned patients (140 patients) who were admitted to the intensive care unit (ICU) of Khorshid Hospital, Isfahan, Iran, between January 2015 and 2019.

Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome.

Background/objectives: Rare genetic disorders causing specific congenital developmental abnormalities often manifest in single families. Investigation of disease-causing molecular features are most times lacking, although these investigations may open novel therapeutic options for patients. In this study, we aimed to identify the genetic cause in an Iranian patient with severe skeletal dysplasia and to model its molecular function in zebrafish embryos.

Net water uptake as a predictive neuroimaging marker for acute ischemic stroke outcomes: a meta-analysis.

Objective: To assess the role of net water uptake (NWU) in predicting outcomes in acute ischemic stroke (AIS) patients.

Methods: A systematic review and meta-analysis were performed, adhering to established guidelines. The search covered PubMed, Scopus, Web of Science, and Embase databases until July 1, 2023.

The Effect of Hydroalcoholic Extract of and Boiss Against .

Objective: Trichomoniasis is the most common sexually transmitted protozoan infection worldwide. Metronidazole is widely considered as the drug of choice for treating of trichomoniasis but considering its potential side effects, we aimed to assess the therapeutic influences of hydro-alcoholic extracts of and Boiss as alternative medications against .

Methods: The trophozoites were cultured in TYI-S-33 medium at a density of 5x10 trophozoites/mL.

Applications of Innovation Technologies for Personalized Cancer Medicine: Stem Cells and Gene-Editing Tools.

Personalized medicine is a new approach toward safer and even cheaper treatments with minimal side effects and toxicity. Planning a therapy based on individual properties causes an effective result in a patient's treatment, especially in a complex disease such as cancer. The benefits of personalized medicine include not only early diagnosis with high accuracy but also a more appropriate and effective therapeutic approach based on the unique clinical, genetic, and epigenetic features and biomarker profiles of a specific patient's disease.

A computational investigation of DMSO/water separation through functionalized GO multilayer nanosheet membrane using molecular dynamics simulation and deep neural network model for membrane performance prediction.

In this molecular dynamics (MD) simulation study, the separation of dimethyl sulfoxide (DMSO) from water was investigated using multilayer functionalized graphene oxide (GO) membranes. The GO nanosheets were modified with chemical groups (-F, -H) to alter their properties. The study analyzed the influence of pressure and functional groups on the separation rate.

Highly efficient helium purification through a dual-membrane system: insights from molecular dynamics simulations.

Almost all helium is resourced from natural gas reservoirs. Hence, it is essential to develop new efficient technologies to recover helium from natural gas. In this work, we propose a novel dual membrane system, consisting of CN (M1) and graphdiyne (M2) membranes, to separate and purify helium from a ternary gas mixture of He/N/CH.

The Role of Multimodal Imaging in Differentiating Vasogenic from Infiltrative Edema: A Systematic Review.

 High-grade gliomas (HGGs) are the most prevalent primary malignancy of the central nervous system. The tumor results in vasogenic and infiltrative edema . Exact anatomical differentiation of these edemas is so important for surgical planning.

Organized physical activity and sedentary behaviors in children and adolescents with autism spectrum disorder, cerebral palsy, and intellectual disability.

Background: There is little data on physical activity (PA), organized PA (OPA), and sedentary behaviors in autism spectrum disorders (ASD) and other neurodevelopmental disorders in developing countries.

Aim: To examine OPA, non-OPA, and sedentary behaviors and their associated factors in children and adolescents with ASD, cerebral palsy (CP), and intellectual disability (ID).

Methods: A total of 1020 children and adolescents with ASD, CP, and ID were assessed regarding the child and family information as well as the Children's Leisure Activities Study Survey.