Antioxidant and antibacterial activities of 5-mercapto(substitutedthio)-4-substituted-1,2,4-triazol based on nalidixic acid: A comprehensive study on its synthesis, characterization, and evaluation.

This study introduces a series of novel Alkyl thio-1,2,4-triazole () and mercapto-1,2,4-triazole () compounds derived from nalidixic acid. The synthesis was streamlined, involving interactions between nalidixic acid hydrazide and various isothiocyanates to yield cyclic and alkyl(aryl) sulfide compounds, characterized using 1H NMR, 13C NMR, IR, and elemental analysis. Antioxidant capabilities were quantified through DPPH and ABTS assays, highlighting significant potential, especially for compound , which demonstrated an ABTS IC value of 0.

Synthesis, characterization, computational, antioxidant and fluorescence properties of novel 1,3,5-trimesic hydrazones derivatives.

New photophysical and antioxidant materials of trimesic trihydrazide derivatives were synthesized by one-pot stage of trimesic trihydrazide and different aromatic aldehydes. All compounds were characterized by spectroscopic techniques (NMR, MS, and IR) and elemental analysis. The absorption and emission spectral characteristics of hydrazone derivatives were investigated.

Chemical constituents of the aerial parts of Boiss. from Jordan.

Investigation of the chemical constituents of growing wild in Jordan led to the isolation and identification of 15 known compounds. These included: luteolin-3'-methyl ether (), indole-3-carboxyaldehyde (), -hydroxybenzaldehyde (), tricin (), apigenin (), methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (), methyl rosmarinate (, rosmarinic acid (), salvigenin (), -sitosterol (), 3, 28-dihydroxyurs-12-ene (), cirsilineol (), 2,3-dihydroxyurs-12-en-28-oic acid (), -sitosteryl glucoside (), and tormentic acid (). Compounds and exhibited strong radical scavenging and chelating activities as compared to α-tocopherol and ascorbic acid, compound showed a 2-fold greater antioxidant activity as compared to compound .

New isoflavones from Gynandriris sisyrinchium and their antioxidant and cytotoxic activities.

Chemical investigation of Gynandriris sisyrinchium (L.) Parl growing in Jordan resulted in the isolation and characterization of a total of twelve compounds two of which are reported here for the first time in nature. These new compounds included the isoflavones; 3'-methyl tenuifone (2) and gynandrinone (5).

A notable antimutagenicity of two nonmutagenic novel oxadiazoles in Salmonella mutagenicity assay.

The mutagenic activity of two newly synthesized oxadiazoles: 1,3-bis(5-benzylthio-1,3,4-oxadiazol-2-yl) benzene (M1) and 1,4-bis(5-benzylthio-1,3,4-oxadiazol-2-yl) benzene (M2) was studied in Salmonella typhimurium strains TA97, TA100, TA102 and TA1537 in the presence and absence of S9mix. The antimutagenicity of M1 and M2 against H2O2, sodium azide (SA) and 4-nitro-o-phenylene diamine (NPD) using the tester strains TA102, TA100 and TA97, respectively, was also investigated. The two compounds were found to be nonmutagenic using the four tester strains.

Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives.

In the present investigation, four 1,3,4-bis-oxadiazole derivatives were synthesized as potential antimicrobial agents. The compounds are: 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]propane (2a), 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]butane (2b), 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]octane (2c) and 5,5'-dibenzylthio-bis-[1,3,4-oxadiazol-2-yl]butane (3). The above newly synthesized compounds were investigated for their antibacterial, antifungal and mutagenic activities.