Publications by authors named "Hasan Jozilan"
Article Synopsis
- - The study investigates how 1,25-Dihydroxy vitamin D affects antitumor activity in liver cancer (hepatocellular carcinoma) by analyzing gene expressions related to vitamin D metabolism in cancerous versus normal liver tissues.
- - Researchers found that in liver cancer tissues, the key genes that activate vitamin D (VDR and CYP27B1) were significantly lower, while the gene associated with inactivating vitamin D (CYP24A1) was expressed.
- - These findings suggest that liver cancer may reduce the effectiveness of 1,25-Dihydroxy vitamin D's tumor-fighting properties, highlighting a potential mechanism of cancer evasion from vitamin D's antitumor effects.
Aim: 1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits cell growth and induces apoptosis in numerous types of tumors. We aimed to examine the mRNA and protein expression of 1,25(OH)(2)D(3)-inactivating CYP24A1 and mRNA expression of the activating CYP27B1 enzymes, as well as that of vitamin D receptor (VDR), in hepatocellular carcinoma (HCC) cell cultures in response to 1,25(OH)(2)D(3) administration.
Materials And Methods: Increasing amounts of 1,25(OH)(2)D(3) (0.