Does Sugammadex Suppress Allergic Inflammation Due to Rocuronium in Animal Model of Rat?

Introduction And Objectives: There are a few reports in the literature about the successful use of sugammadex in the treatment of hypersensitivity reactions caused by rocuronium; however, the pathophysiological mechanism is still unknown. This study aims to investigate the changes caused by rocuronium in the lung and the effect of sugammadex on these changes with biochemical, light microscopic and immunohistochemical parameters on a rat model.

Materials And Methods: For the study, 28-male Sprague-Dawley rats were randomly divided, seven of each, into four groups.