Publications by authors named "Harvinder Mann"
Article Synopsis
- The study investigates how linoleic acid (LA) stabilizes the spike protein of the SARS-CoV-2 virus, potentially reducing its infectivity, and seeks to repurpose FDA-approved drugs to bind to the LA binding site on the spike protein.
- Using computational methods, including virtual screening and molecular dynamics simulations, researchers identified 26 candidate drugs, ultimately narrowing it down to two promising ligands: selexipag and pralatrexate.
- Pralatrexate exhibited better binding affinity than LA and demonstrated in vitro activity against SARS-CoV-2, suggesting its potential as a therapeutic agent.
Objective: To report the early and mid-term outcome of complex endovascular repair (EVAR) for paravisceral infective native aortic aneurysms (INAA).
Methods: Interrogation of a prospectively maintained database identified consecutive patients who underwent non-elective complex EVAR for paravisceral INAAs in a single institution between December 2013 and June 2020. All patients were considered to have definite INAAs based on diagnostic criteria.
Background and objective Laparoscopic cholecystectomy is used for the treatment of symptomatic gallstones. Intraoperative cholangiogram (IOC) is used to diagnose common bile duct (CBD) stones. There is controversy surrounding routine vs selective use of IOC based on clinical, biochemical and ultrasound criteria.
View Article and Find Full Text PDFEpitope prediction is becoming a key tool for vaccine discovery. Prospective analysis of bacterial and viral genomes can identify antigenic epitopes encoded within individual genes that may act as effective vaccines against specific pathogens. Since B-cell epitope prediction remains unreliable, we concentrate on T-cell epitopes, peptides which bind with high affinity to Major Histacompatibility Complexes (MHC).
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