Inflammation severity, rather than respiratory failure, is strongly associated with mortality of ARDS patients in high-altitude ICUs.

Introduction: In high-altitude cities located above 2,500 m, hospitals face a concerning mortality rate of over 50% among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS). This elevated mortality rate is largely due to the absence of altitude-specific medical protocols that consider the unique physiological adaptations of high-altitude residents to hypoxic conditions. This study addresses this critical gap by analyzing demographic, clinical, sex-specific, and preclinical data from ICUs in Bogotá, Colombia (2,650 m) and El Alto, Bolivia (4,150 m).

Active disturbance rejection control based on a cascade estimator composed of reduced-order and full-order extended state observers.

This paper presents a pioneering cascade estimator, CRESO, which merges reduced-order and full-order extended state observers (ESO) in a novel manner. CRESO is designed to navigate the trade-off between robustness, estimation accuracy, and noise amplification inherent in active disturbance rejection control (ADRC) schemes. An analysis in the frequency domain substantiates CRESO's performance and robustness capabilities compared to those of single-level ESO and cascade ESO (CESO).

On the equivalence between Generalized Proportional Integral Observer and Disturbance Observer.

This paper presents the equivalence between generalized proportional integral observer (GPIO) and disturbance observer (DOB), which is applicable to reduced-order GPIO (ROGPIO), full-order GPIO (FOGPIO), and extended state observer (ESO). From this equivalence, established in frequency-domain, comprehensive analyses are performed regarding the influence of the system order, the number of extended states, the uncertain control gain, and the tuning method on the robustness and performance of GPIO. In addition, the equivalence allows a detailed comparison between ROGPIO and FOGPIO in the active disturbance rejection control (ADRC) framework.