Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning.

Purpose: Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to examine the efficacy of cryotherapy among allo-HSCT recipients treated with Mel-containing regimens.

Methods: Medical records of 78 consecutive allo-HSCT recipients were retrospectively analyzed.

Effect of Dietary Protein Levels on Protein Nutritional Status in Growing Female Rats Kept under Constant Darkness.

The purpose of this study was to clarify the effects of dietary protein levels on protein nutritional status in rats kept under constant darkness. Thirty-six 4-wk-old female rats (F344 strain) were divided into six groups. Each group was given a diet with one of three different protein levels and kept under normal light and dark cycles (7:00-19:00 light period/19:00-7:00 dark period, N group) or under constant darkness (D group) for 4 wk.