Curcumin protects against acoustic trauma in the rat cochlea.

Objectives: In this study we evaluated the therapeutic utility of curcumin in a rodent model of acoustic trauma using histopathology, immunohistochemical, and distortion product otoacoustic emission (DPOAEs) measurements.

Methods: 28 Wistar albino rats were included in the study and randomly assigned to 4 treatment groups. The first group (group 1) served as the control and was exposed to acoustic trauma alone.

Intraperitoneal curcumin and vitamin E combination for the treatment of cisplatin-induced ototoxicity in rats.

Introduction: Cisplatin ototoxicity is characterized by irreversible, progressive, bilateral sensorineural hearing loss at high frequencies, accompanied by tinnitus. The aim of this study is to demonstrate the protective action of curcumin alone or in combination with vitamin E against cisplatin-induced ototoxicity in animal models.

Material And Methods: The study included 42 rats.

Comparison of Endoscopic and External Dacryocystorhinostomy Results and Analysis of Patients' Satisfaction.

Objective: Comparison of endoscopic and external dacryocystorhinostomy (DCR) results and evaluation of patients' satisfaction.

Methods: Forty six (35 females and 11 males) patients who underwent endoscopic DCR and 43 (37 females and six males) who underwent external DCR were included. Surgical success was objectively and subjectively assessed.

The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats.

Introduction: The ethiopathogenesis of tympanosclerosis has not been completely under- stood yet. Recent studies have shown that free oxygen radicals are important in the formation of tympanosclerosis. Melatonin and Vitamin C are known to be a powerful antioxidant, interacts directly with Reactive Oxygen Species and controls free radical-mediated tissue damage.

MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia.

Conclusion: A significant association was found of oropharyngeal tularemia with SLC11A1 allele polymorphism (INT4 G/C) and MBL2 C + 4T (P/Q). These results indicate C allele and Q allele might be a risk factor for the development of oropharyngeal tularemia.

Aim: This study aimed to investigate the relationship of SLC11A1, MBL, and P2X gene polymorphism with oropharyngeal tularemia.

Protective effects of melatonin and selenium against apoptosis of olfactory sensory neurons: A rat model study.

Background: Selenium plays a role in the prevention of oxidative damage and has been linked to regulatory functions in cell growth, apoptosis, cell survival, and cytotoxicity. Melatonin has an antioxidant effect, which protects against a number of free radical species. Given its antioxidant properties, melatonin has been widely known to inhibit neuronal apoptosis.

Paraoxonase Activity and Oxidative Status in Patients with Tinnitus.

Background And Objectives: The aim of this study was to investigate serum paraoxanase-1 (PON) activity, total oxidant status (TOS), total antioxidant status (TAS), and the oxidative stress index (OSI) in tinnitus; and to compare the results with data from healthy subjects.

Subjects And Methods: A total of 114 subjects-54 patients with tinnitus and 60 healthy controls were enrolled in this study. Serum PON activity, TOS, TAS, and OSI levels were measured.

Evaluation of iron and zinc levels in recurrent tonsillitis and tonsillar hypertrophy.

Objectives: The aim of this study is to look into the roles of iron and zinc metals in etiopathogenesis of recurrent tonsillitis and tonsillar hypertrophy by evaluating the levels of iron and zinc elements in the palatine tonsillar tissue.

Methods: In total, 40 patients who underwent a tonsillectomy to treat recurrent tonsillitis and tonsillar hypertrophy were included in the study. Patients were classified into two groups, recurrent tonsillitis and tonsillar hypertrophy, determined by the results of clinical and histopathological examination.

Post-radiotherapy bilateral external auditory canal cholesteatoma.

In this article, we report a 55-year-old female case was treated with radiotherapy due to nasopharynx carcinoma and diagnosed with bilateral external auditory canal cholesteatoma four years after radiotherapy. Persistent otorrhea was present in the patient and the diagnosis was established through noticing a soft tissue mass eroding external auditory canal anterior wall in temporal bone tomography as well as the otoscopic findings. Canaloplasty and cholesteatoma excision were administered as the surgical treatment.

Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome.

Objectives: This study aims to determine the association between obstructive sleep apnea syndrome (OSAS) caused by adenotonsillar hypertrophy and mean platelet volume (MPV) and MPV/platelet count ratio in children, and to evaluate the impact of adenotonsillectomy on these two parameters.

Patients And Methods: This prospective study consisted of 73 child patients (38 boys, 35 girls; mean age 8.6±3.

Vestibular evoked myogenic potentials in pediatric patients with familial Mediterranean fever.

Objectives: We aimed to investigate whether the chronic autoinflammatory process in familial Mediterranean fever (FMF), which affects numerous systems, results in vestibular dysfunction in pediatric patients being followed up for diagnosis of FMF using VEMP recordings.

Methods: 30 patients (60 ears) diagnosed with FMF and 20 (40 ears) healthy volunteers were included in the study. Following routine ear, nose, and throat examination, transient-evoked otoacoustic emissions (TEOAE) and vestibular-evoked myogenic potential (VEMP) tests were performed.

Mean platelet volume as an inflammatory marker of chronic otitis media with effusion.

Objectives: Our aim was to investigate whether mean platelet volume (MPV) may be utilized as an inflammatory marker of chronic otitis media with effusion (COME).

Methods: Routine hemogram tests were performed preoperatively for 51 patients diagnosed with COME that were to receive ventilation tube insertion. Hemogram tests were performed on age-matched and sex-matched healthy controls (n=54).

Investigation of the synergism between alcohol consumption and herpes simplex virus in patients with laryngeal squamous cell cancers.

We investigated the synergism between alcohol consumption and herpes simplex virus (HSV) in the development of laryngeal squamous cell cancer and in the clinical course of this disease. HSV DNA was searched by polymerase chain reaction (PCR) technique in the fresh tumor tissues of 22 patients with laryngeal cancer without alcohol consumption (Group 1) and of 23 patients with chronic alcohol consumption (Group 2), and their HSV prevalences were compared. No statistically significant difference was detected between the two groups in terms of HSV incidence frequency (P > 0.