Publications by authors named "Harumi Yamakawa"
The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via expression in male mice.
Proc Natl Acad Sci U S A
September 2024
Article Synopsis
- Androgens influence muscle quality by binding to androgen receptors (AR), primarily in nonmyofiber cells rather than directly affecting muscle mass.
- This study shows that when AR is removed from mesenchymal progenitors, it decreases muscle mass in adult male mice, leading to muscle atrophy and affecting gene regulation related to cell death and tissue structure.
- Additionally, the research found that AR helps regulate insulin-like growth factor 1 (Igf1), which can counteract muscle loss, underlining the importance of AR in maintaining skeletal muscle mass through mesenchymal progenitors.