An unusual case of hypopituitarism and transient thyrotoxicosis following asymptomatic pituitary apoplexy.

Although pituitary function is often impaired in pituitary apoplexy, the development of thyrotoxicosis is rare. We describe an unusual case of hypopituitarism due to pituitary apoplexy coexisting with transient hyperthyroidism. A 74-year-old woman presented with severe fatigue, palpitation, appetite loss, hypotension, and hyponatremia.

Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.

Ethnopharmacological Relevance: Aquaporin-3 (AQP3) is expressed in mucosal epithelial cells in the colon and is important for regulating fecal water content. We examined the role of AQP3 in the laxative effect of rhubarb extract.

Methods: After orally administering rhubarb extract or its major component (sennoside A) to rats, the fecal water content, AQP3 expression and prostaglandin E2 (PGE2) concentrations in the colon were examined.

Byakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin-2 and skin aquaporin-3 in KKAy mice.

Byakkokaninjinto (BKN) is an herbal medicine used for the relief of diuresis, thirst and dermal pruritus that are associated with diabetes. The effects of BKN on the expression of aquaporins (AQPs) in the kidney, salivary gland and skin were investigated in order to clarify the mechanism of drug action. Seven-week-old KKAy mice were given feed containing 4.

Relationship among workload, health complaints, and depressive state of workers as revealed using a questionnaire survey.

Objective: Identifying the relationship between workload content and health complaints would likely aid the establishment of preventative health care strategies.

Participants: The study population consisted of 137 male workers from a pharmaceutical company.

Methods: The workloads of the target subjects were divided into three groups (A, B, and C+D) according to the scores of a self-administered questionnaire.

Body mass index of 23 or more is a risk factor for hypertension and hyperlipidemia in Japanese workers.

In comparison with western populations, body mass index (BMI) of the Japanese population is typically lower. In this study, the relationship between BMI and other metabolic risk factors was examined in 1,130 male manufacturing workers surveyed from 2000 to 2003. The association between the BMI and the relative risk of hypertension was evaluated in a cross-sectional design using logistic regression analysis.