Synthesis, Characterization, and Thin-Film Properties of Post-Functionalized N,N-Dimethylanilinoethynyl-Substituted Cyclobutenofullerenes.

A π-extended cyclobutenofullerene containing an N,N-dimethylanilinoethynyl group was synthesized via a one-pot cascade reaction of C with the corresponding propargylic phosphate. The cyclobutenofullerene was further modified using either one-pot or sequential post-functionalization methods, yielding derivatives containing altered addend structures. During one-pot post-functionalization, hydration reaction of the alkyne moiety continued after the formation of cyclobutenofullerenes.

Changes in mutagenicity and acute toxicity of solutions of iodinated X-ray contrast media during chlorination.

In the present study, the effects of chlorination on the mutagenicity (assessed via the Ames assay) and acute toxicity (assessed via a bioluminescence inhibition assay) of solutions containing one of five commonly used iodinated X-ray contrast media (ICM) (iopamidol, iohexol, iopromide, iomeprol, and diatrizoate) were investigated. Of the five ICM tested, only iopamidol was degraded by chlorine. Chlorination of the iopamidol-containing solution induced both mutagenicity and acute toxicity, which increased with chlorination time (up to 96 h).