Publications by authors named "Haruki Okubo"
Biol Pharm Bull
July 2019
Article Synopsis
- The study examined how seleno-L-methionine (SeMet) affects allergic responses in rat basophilic leukemia (RBL-2H3) cells by focusing on IgE-mediated reactions.
- Treatment with SeMet was found to significantly inhibit key indicators of degranulation, including the release of β-hexosaminidase and calcium mobilization triggered by the allergen.
- SeMet also reduced the expression and secretion of inflammatory proteins IL-4 and TNF-α, and inhibited the activation of critical signaling pathways (Syk, Akt, and MAPKs) associated with allergic responses, suggesting potential therapeutic benefits for managing allergies.
