Carbon powder-filled microelectrode: An easy-to-fabricate probe for cellular electrochemistry.

Carbon fiber and carbon fiber disc microelectrodes are widely used for electrochemical detection of biochemicals released from cells. However, fabricating these types of microelectrodes is difficult and time-consuming. Here, we report an easy-to-fabricate, carbon powder-filled microelectrode consisting of a pulled glass capillary backfilled with carbon powder.

A test potential booster for fast-scan cyclic voltammetry with an electrophysiological amplifier.

Fast-scan cyclic voltammetry (FSCV) is a powerful technique for studying the local dynamics of neurotransmitters and neuromodulators. FSCV is attractive to researchers employing electrophysiological techniques because it can be performed using an electrophysiological voltage-clamp amplifier. However, the narrow test potential range of electrophysiological amplifiers (typically, ±1 V) limits testable species of analytes.

Automated classification of hip fractures using deep convolutional neural networks with orthopedic surgeon-level accuracy: ensemble decision-making with antero-posterior and lateral radiographs.

Background and purpose - Deep-learning approaches based on convolutional neural networks (CNNs) are gaining interest in the medical imaging field. We evaluated the diagnostic performance of a CNN to discriminate femoral neck fractures, trochanteric fractures, and non-fracture using antero-posterior (AP) and lateral hip radiographs. Patients and methods - 1,703 plain hip AP radiographs and 1,220 plain hip lateral radiographs were included in the total dataset.

[Risk factors for cardiotoxicity during fluorouracil and cisplatin combination chemotherapy].

We investigated the incidence of cardiovascular symptoms in patients treated with fluorouracil and cisplatin (FP) combination chemotherapy. Between April 2010 and March 2011, 61 patients were treated with FP therapy at the Department of Gastroenterology, Niigata Prefectural Cancer Center Hospital. Within 1 week of treatment and within the first or second course of therapy, six patients developed chest pain.

[Prophylaxis with acyclovir for herpes zoster infection during bortezomib-dexamethasone combination therapy].

A novel molecular targeting drug, a proteasome inhibitor, bortezomib (Bor), has been reported to be highly effective for relapsed/refractory, as well as for newly diagnosed multiple myeloma, but is also associated with a high frequency of herpes zoster (HZ) infection (13%). We conducted a retrospective survey on HZ infection (profile) after Bor therapy in our hospital. Six of 30 patients developed HZ infection during bortezomib-dexamethasone treatment (BD therapy).