Publications by authors named "Haruki Kasama"
Article Synopsis
- The study investigates how cytotrophoblast cells differentiate into extravillous trophoblast (EVT) and interact with maternal immune cells during early pregnancy, focusing on the role of chemokines in this process.
- Researchers used a three-dimensional culture model of Swan71 cells to analyze gene and protein expressions related to chemokines and EVT markers, discovering that certain chemokines were significantly upregulated compared to monolayer cultures.
- The findings suggest that the spheroid culture model enhances chemokine expression, which may facilitate the migration of immune cells, highlighting the importance of chemokines in the EVT's early development and interaction with the maternal immune system.
Background: Since the human papillomavirus vaccines do not eliminate preexisting infections, nonsurgical alternative approaches to cervical intraepithelial neoplasia (CIN) have been required. We previously reported that FOXP4 (forkhead box transcription factor P4) promoted proliferation and inhibited squamous differentiation of CIN1-derived W12 cells. Since it was reported that FOXP expressions were regulated by the androgen/androgen receptor (AR) complex and AR was expressed on the CIN lesions, in this study we examined the effects of androgen on CIN progression.
View Article and Find Full Text PDFAlthough the human papillomavirus (HPV) vaccine is effective for preventing cervical cancers, this vaccine does not eliminate pre-existing infections, and alternative strategies have been warranted. Here, we report that FOXP4 is a new target molecule for differentiation therapy of cervical intraepithelial neoplasia (CIN). An immunohistochemical study showed that FOXP4 was expressed in columnar epithelial, reserve, and immature squamous cells, but not in mature squamous cells of the normal uterine cervix.
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