Systemic cisplatin increases the number of patients showing positive off-frequency masking audiometry.

Objective: The study aimed to evaluate the effect of systemic cisplatin administration on off-frequency masking audiometry.

Methods: Among 26 patients receiving systemic cisplatin, 48 ears were included in the analysis. All patients underwent pure-tone audiometry with ipsilateral narrow-band masking noise (off-frequency masking audiometry).

Effect of hearing aids on body balance function in non-reverberant condition: A posturographic study.

Objective: The purpose of this study was to evaluate the effect of hearing aids on body balance function in a strictly controlled auditory environment.

Methods: We recorded the findings of 10 experienced hearing aid users and 10 normal-hearing participants. All the participants were assessed using posturography under eight conditions in an acoustically shielded non-reverberant room: (1) eyes open with sound stimuli, with and without foam rubber, (2) eyes closed with sound stimuli, with and without foam rubber, (3) eyes open without sound stimuli, with and without foam rubber, and (4) eyes closed without sound stimuli, with and without foam rubber.

Multicenter Study of Congenital Middle Ear Anomalies. Report on 246 Ears.

Objectives/hypothesis: Congenital middle ear anomalies represent a relatively rare condition. This study aimed to describe the characteristics and the surgical outcomes for patients with middle ear anomalies.

Methods: A multicenter study was conducted of consecutive patients with congenital middle ear anomalies who underwent primary surgical treatment between January 2008 and December 2017.

A Case of Actinomycosis in the Rosenmüller's Fossa.

Actinomycosis is an infrequent infectious disease caused by species. Actinomycoses in the nasopharynx are extremely rare, especially in the Rosenmüller's fossa. This report presents a case of actinomycosis in the Rosenmüller's fossa.

Central processing of speech sounds and non-speech sounds with similar spectral distribution: An auditory evoked potential study.

Objective: The purpose of this study was to measure the auditory evoked potentials for speech and non-speech sounds with similar spectral distributions.

Methods: We developed two types of sounds, comprising naturally spoken vowels (natural speech sounds) and complex synthesized sounds (synthesized sounds). Natural speech sounds consisted of 5 Japanese vowels.

Detectability of minute temporal bone structures with ultra-high resolution CT.

Objective: Computed tomography (CT) is the imaging tool of choice in the diagnosis of temporal bone lesions. With the recent progress in imaging technology, CT with higher spatial resolution (Ultra-high resolution CT) has become available in the clinical setting. The purpose of this study is to evaluate the visibility of small temporal bone structures using ultra-high resolution CT.

Intraoperative Evaluation of Cochlear Implant Electrodes Using Mobile Cone-Beam Computed Tomography.

Objective: To evaluate the electrode status during cochlear implantation (CI) using mobile cone-beam CT (mCBCT).

Study Design: Retrospective case review.

Setting: Tertiary referral hospital.

Body balance function of cochlear implant patients with and without sound conditions.

Objective: The relation between well-controlled auditory stimulation through cochlear implant (CI) and the body balance has been sparsely investigated. The purpose of this study was to evaluate the body balance function of CI patients with- and without-sound in anechoic sound-shielded room.

Methods: We recorded 8 experienced CI recipients and 8 young normal-hearing volunteers.

Cochlear implant function in a patient with Jervell and Lange-Nielsen syndrome after defibrillation by countershock.

Jervell and Lange-Nielsen syndrome (JLNS), a rare autosomal recessive congenital QT prolongation syndrome, is characterized by cardiac arrhythmias, syncopal episodes, and profound deafness. A cochlear implant (CI) for patients with JLNS is expected to result in hearing improvement. Sometimes, defibrillation is required if a patient experiences lethal arrhythmia.

Histopathological evaluation and long-term results of soft tissue preservation technique in cholesteatoma surgery.

The goal of cholesteatoma surgery is total removal of the cholesteatoma matrix and prevention of recurrence. Preservation of soft tissue in the attic is reported to improve post-operative middle ear aeration, and thus prevents recurrence. However, the histology and nature of the preserved tissue have rarely been reported.

Temporal bone chondroblastoma totally invisible on MRI.

We report a case of temporal bone chondroblastoma that was totally invisible on MRI. The patient was a 64-year-old man who presented with several months history of vertigo. The CT scan with bone window setting showed destruction of the temporomandibular joint, the floor of the middle cranial fossa, and the superior semicircular canal.

Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study.

Objective: To determine the prognostic factors for hearing recovery in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic corticosteroids following salvage treatment.

Methods: This is a retrospective observational study at nine tertiary referral hospitals. A total of 120 patients with sudden deafness refractory to systemic corticosteroids were enrolled.

The Outcome of Cochlear Implantation for Mitochondrial Disease Patients With Syndromic Hearing Loss.

Objectives: To evaluate the outcome and to confirm the validity of cochlear implantation for syndromic deafness in patients with mitochondrial disease.

Study Design: Retrospective case review.

Setting: Tertiary referral center.

The sensitivity and accuracy of a cone beam CT in detecting the chorda tympani.

The facial recess approach through posterior tympanotomy is the standard approach in cochlear implantation surgery. The size of the facial recess is highly variable, depending on the course of the chorda tympani. Despite their clinical importance, little is known about the sensitivity and accuracy of imaging studies in the detection of the chorda tympani.

A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment.

Background: To date, no therapeutic option has been established for sudden deafness refractory to systemic corticosteroids. This study aimed to examine the efficacy and safety of topical insulin-like growth factor-1 (IGF-1) therapy in comparison to intratympanic corticosteroid therapy.

Methods: We randomly assigned patients with sudden deafness refractory to systemic corticosteroids to receive either gelatin hydrogels impregnated with IGF-1 in the middle ear (62 patients) or four intratympanic injections with dexamethasone (Dex; 58 patients).

Peripheral facial palsy caused by neoplastic meningitis.

Objectives/hypothesis: To describe the clinical presentation of peripheral facial palsy caused by neoplastic meningitis.

Study Design: Retrospective case series.

Methods: Retrospective review, including accompanying symptoms and magnetic resonance imaging (MRI) findings.

Preattentive processing of horizontal motion, radial motion, and intensity changes of sounds.

Localization of sound sources is critical for an appropriate behavioral response. This is not only true for localization in the horizontal plane but also for localization in depth. Depth ranging of sound sources implicates various distance cues, among others sound intensity.

Detection of the petrosquamosal sinus in chronic otitis media using high-resolution CT.

Objective: To evaluate the prevalence of the persistent petrosquamosal venous sinus in patients with chronic otitis media using a high-resolution CT scan.

Study Design: Retrospective chart review.

Setting: Tertiary referral center.

Rapid detection of bacterial DNA in mastoid granulation tissue with nested-PCR technique.

Objective: To detect bacterial DNA in mastoid granulation tissue from patients with chronic suppurative otitis media (CSOM).

Material And Method: A two-step polymerase chain reaction (nested polymerase chain reaction) technique was employed. A 16s rRNA universal primer common to all bacteria was used as a bracket primer for the first step PCR reaction.

Systemic steroid application caused sudden death of a patient with sudden deafness.

A 63-year-old man, who was diagnosed with sudden sensorineural hearing loss (SSHL), showed severe hypertension 10 hours after prednisolone administration. Subsequently, the patient suddenly died due to pulmonary edema. The autopsy indicated a pheochromocytoma in the right adrenal gland, and the cause of death was determined to be a pheochromocytoma crisis induced by systemic administration of prednisolone.

Improvement of eustachian tube function by tissue-engineered regeneration of mastoid air cells.

Objectives/hypothesis: Most cases of chronic otitis media (OMC) are associated with poor development of the mastoid air cells (MACs) and poor Eustachian tube (ET) function. We have previously reported that MAC regeneration can effectively eliminate intractable OMC. In this study, we assessed the ability of regenerated MACs to restore normal gas exchange function and contribute to improved ET function.

Audiometric outcomes of topical IGF1 treatment for sudden deafness refractory to systemic steroids.

Objective: To examine the effects of topically applied recombinant human insulin-like growth factor 1 (IGF1) via gelatin hydrogels on alterations in pure-tone audiometry (PTA) in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic steroids.

Study Design: Retrospective chart review.

Setting: A single university hospital.