Publications by authors named "Haruka Tokuyama"
Article Synopsis
- Pomalidomide, a thalidomide derivative, is a potent treatment for multiple myeloma, acting through CRBN in the CRL4 E3 ubiquitin ligase complex.
- A genome-wide shRNA screen discovered 445 genes influencing sensitivity to pomalidomide, highlighting the role of the ubiquitin-proteasome pathway.
- Karyopherin beta 1 (KPNB1) is a key gene necessary for the nuclear import of CRBN and affects the degradation of the transcription factor Aiolos, underscoring the importance of CRBN's subcellular location in the drug’s effectiveness.
Earthworms contain several digestive and therapeutic enzymes that are beneficial to our health and useful for biomass utilization. Specifically, earthworms contain potent fibrinolytic enzymes called lumbrokinases, which are highly stable even at room temperature and remain active in dried earthworm powder. However, the high-temperature sterilization method leads to the inactivation of enzymes.
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