[Pharmacological and clinical study results of Berotralstat Hydrochloride for long-term prophylactic treatment of hereditary angioedema].

Hereditary angioedema (HAE) is a rare disease that causes serious health problem and affects on quality of life for patient due to recurrent episodes of angioedema in various body such as the skin, larynx, digestive tract, and limbs. Many HAE patients have deficiency or dysfunction of C1 inhibitor, impaired regulation of plasma kallikrein activity and overproduction of bradykinin, resulting in leading to episodes of increased capillary hyper permeability and angioedema. Therapy of HAE consists of on-demand treatment for acute attack and prophylactic treatment by suppressing the onset of acute attack in the short and long term.

Effect of Ultraviolet Irradiation on Proton Transfer Facilitated by 5,10,15,20-Tetraphenyl-21H,23H-porphine and Its Metal Complexes at a Water/1,2-Dichloroethane Interface.

We examined photochemical effects by ultraviolet irradiation on facilitated proton transfer at a water/1,2-dichloroethane (W/DCE) interface by ion-transfer voltammetry using a Xe flash lamp. 5,10,15,20-Tetraphenyl-21H,23H-porphine (HTPP) or its metal complex, such as cobalt (Co(II)TPP), zinc (Zn(II)TPP), and nickel (Ni(II)TPP) complexes, was added into the DCE phase as an ionophore for the facilitated proton transfer. After we irradiated the W/DCE interface through the W phase, the voltammetric waves for proton transfer facilitated by HTPP and Co(II)TPP were remarkably enhanced and shifted to the lower potential region, compared to those before irradiation.