Publications by authors named "Haruka Hosoki"
A Cellulose-Rich Diet Disrupts Gut Homeostasis and Leads to Anxiety through the Gut-Brain Axis.
ACS Pharmacol Transl Sci
October 2024
Article Synopsis
- A healthy gut environment is linked to better mental health, with dietary fiber playing a key role in maintaining this environment; however, previous studies focused mainly on soluble fiber.
- A new study found that mice fed a cellulose-rich diet (insoluble fiber) displayed increased anxiety and intestinal issues, such as lower short-chain fatty acid levels and increased gut permeability.
- The observed increase in anxiety was connected to changes in brain signaling through the gut-brain axis, with specific effects on dopamine signaling in the amygdala, highlighting the potential negative impact of consuming only insoluble fiber like cellulose on mental health.
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- The study investigates the effects of resistant dextrin and magnesium oxide (MgO) on improving constipation and their roles in producing beneficial compounds like short-chain fatty acids (SCFA) and lactic acid through gut microbiota.
- In mice, low doses of MgO increased SCFA and lactic acid production, while high doses had the opposite effect; additionally, when humans consumed both resistant dextrin and Mg supplements, there was an increase in these beneficial compounds.
- The findings suggest that magnesium is necessary for gut microbiota to generate SCFA and lactic acid from resistant dextrin, highlighting the potential of combining these treatments for better digestive health.