Congenital cardiac anomalies: prenatal readings versus neonatal outcomes.

Objective: The purpose of this study was to determine the variation between prenatal and postnatal diagnosis of congenital cardiac lesions diagnosed by both fetal center primary physicians and fetal pediatric cardiologists at a single tertiary referral center in the United States and evaluate why cases were misdiagnosed.

Methods: A retrospective review of all cardiac abnormalities identified prenatally by level II sonography at a tertiary referral fetal center between January 2006 and December 2008 was performed to include any patient with a fetal cardiac abnormality and with a documented autopsy or neonatal follow-up. Congenital heart disease diagnoses were classified as correct, incorrect, or incorrect but within the same spectrum of disease.

Diagnosis of fetal limb abnormalities before 15 weeks: cause for concern.

Objectives: The purposes of this study were (1) to identify cases of limb abnormalities identified before 15 weeks and correlate with outcomes and (2) to assess first-trimester nuchal translucency examinations to determine how frequently the upper and lower limbs were identified.

Methods: A retrospective review was conducted of sonographic studies up to 15 weeks' gestational age from 2003 to 2010 at our high-risk fetal center. Data were collected regarding fetal gestational age, limb abnormalities, associated anatomic abnormalities, pregnancy outcomes, karyotypes, autopsy results, and the utility of transabdominal sonography, transvaginal sonography, and 3-dimensional sonography.

Neuropsychological sequelae of exposure to welding fumes in a group of occupationally exposed men.

This study compares the neuropsychological function, emotional status, visual function, and illness prevalence of 76 former and current chemical industry welders primarily involved in steel welding, and exposed to welding fumes for an average of 24.9 years with that of 42 unexposed, non-welder controls. Health and occupational history questionnaires were administered, as were the neuropsychological tests included in the World Health Organization Neurobehavioral Core Test Battery, Luria Motor Test, and selected tests from the WAIS-III, and WMS-III.

Amnestic disturbance and posttraumatic stress disorder in the aftermath of a chemical release.

Neuropsychological assessments were performed on 70 patients referred after a Catacarb chemical release in a Northern California town. After appropriate exclusions, the 59 patients used in the final analysis were mostly White (66%), with 56% having some college level education. They were administered the: Wechsler Adult Intelligence Scale-Revised (WAIS-R), Memory Assessment Scale (MAS), Trails A and B, Stroop, Controlled Oral Word Association Test (COWAT), Fingertapping Test, Purdue Pegboard, Dynamometer, Rey 15-Item Test, Minnesota Multiphasic Personality Inventory-2 (MMPI-2), Brief Symptom Inventory (BSI), Beck Depression Index (BDI), Profile of Mood States (POMS), and Impact of Events Scale (IES) scales in addition to a health questionnaire and symptom checklist.

Neuropsychological effects of ethylene dichloride exposure.

Production of 1,2-dichloroethane (EDC) has increased and exposure to it has been reported to produce adverse effects in animals and CNS effects in humans. A group of 221 EDC exposed hazardous clean-up workers incurred chronic exposure to EDC without protective equipment. A clinical history and the following tests were administered: the WHO Adult Environmental Neurobehavioral Test Battery (AENTB), Wechsler Adult Intelligence Scale (WAIS-III), Wechsler Memory Scale (WMS-III); WRAT 3 Reading, Cancellation H, Trail Making, Stroop, Rey Osterreith, Animal Naming, COWAT, TOMM, Rey 15, Lanthony d-15 Color Vision, and Vistech Contrast Sensitivity.

Increased medication use in a community environmentally exposed to chemicals.

An epidemiological health study compared the health status of residents of a town exposed to an accidental Catacarb chemical release from an adjacent oil refinery, with the health status of demographically similar residents of an unexposed town in the region. Few studies of Catacarb's effects on humans exist; however, animal studies have shown it to be a respiratory, gastro-intestinal, dermatological and visual irritant. As part of the study, health questionnaires assessing pre- and post exposure symptoms, illnesses and medication use were mailed to residents in both towns.

Neuropsychological dysfunction, mood disturbance, and emotional status of munitions workers.

The objective of this study was to compare the neuropsychological function, emotional status, visual function, and illness prevalence of 265 former munitions plant workers (M age = 56.7 years, M years of education = 12.07; 201 African American, 64 White) exposed to organic solvents for an average of 17.

Epidemiological health study of a town exposed to chemicals.

The purpose of this survey was to assess the health status of community residents exposed to a 16-day release of Catacarb from a nearby refinery and to document the prevalence rates of symptoms and illnesses of this town. The health status of the exposed residents was compared to that of unexposed residents of a demographically similar control town. An epidemiologic study design was used and questionnaires were mailed to all households in both towns.

Symptom base rates after chemical exposure for white, Hispanic and African-Americans.

The results of a symptom checklist of three matched-pair studies (N = 460) of the following exposed groups are presented: Study 1, a primarily white community (N = 220) environmentally exposed to the pesticide metam sodium; Study 2, a Hispanic group (N = 180) who worked in a microelectronics plant and had extensive past exposure (M = 6.7 yrs) to multiple organic hydrocarbon solvents; and Study 3, an African-American group (N = 168) environmentally exposed to sulfuric acid. Each exposed group was compared to a matched (race, age +/- 3 years, gender, education +/- 2 years and number of children) unexposed reference group, resulting in 90 pairs for the white metam sodium group, 62 pairs for the Hispanic organic solvent group, and 78 pairs for the African-American sulfuric acid group.