Publications by authors named "Hartmut B F Pohl"
Article Synopsis
- Myelination requires a significant increase in cell metabolism for lipid and membrane production, with fatty acid synthesis being vital in myelinating glial cells.
- Genetic modification of mice showed that Schwann cells need the enzyme fatty acid synthase (FASN) for proper lipid composition, onset of myelination, and growth of myelin.
- Depleting FASN in Schwann cells triggers lipolysis in nearby adipocytes and disrupts the transcriptional regulation by PPARγ, but these myelination issues can be corrected using the PPARγ agonist rosiglitazone.
Loss of oligodendrocytes is a feature of many demyelinating diseases including multiple sclerosis. Here, we have established and characterized a novel model of genetically induced adult oligodendrocyte death. Specific primary loss of adult oligodendrocytes leads to a well defined and highly reproducible course of disease development that can be followed longitudinally by magnetic resonance imaging.
View Article and Find Full Text PDF