Binding of polylysine to charged bilayer membranes: molecular organization of a lipid.peptide complex.

The interaction between a positively charged peptide (poly-L-lysine) and model membranes containing charged lipids has been investigated. Conformational changes of the polypeptide as well as changes in the membrane lipid distribution were observed upon lipid-protein agglutination: 1. The strong binding of polylysine is shown directly by the use of spinlabelled polypeptide.

The effect of amplitude envelope on the pitch of sine wave tones.

Psychophysical experiments show that the pitch of a short sine wave tone depends upon the amplitude envelope of the tone. Subjects find that the pitch of an exponentially decaying tone (1dB/ms) is higher than the pitch of a (20-ms) rectangularly gated tone of equal frequency. The percentage difference in frequency required to produce equal pitches with the two envelopes depends upon frequency fo: 2.

Studies on the cell cycle of Myxobacter AL-1. II. Activities of seven enzymes during the cell cycle.

The properties of seven enzymes were studied in extracts from Myxobacter AL-1. The enzymes were isocitrate dehydrogenase (E.C.

Changes in bone and bone marrow of rabbits bearing the VX-2 carcinoma. A comparison of local and distant effects.

The VX-2 carcinoma in 32 New Zealand white rabbits was studied morphologically with respect to the osseous effects induced by the innoculation and subsequent growth of tumour in the soft tissues over periods ranging from 1 to 5 weeks. Although more severe changes were noted in bones of tumor-bearing than in non-tumor-bearing limbs, effects could be seen in both experimental situations. Severe bone marrow hyperplasia was noted consistently in tumor-bearing animals.

Brain acetylcholine, adenine nucleotides and their degradation products after intraperitoneal and intracerebral adenosine administration.

The paper describes adenosine effects on the acetylcholine synthesis and the profiles of adenine nucleotides, adenosine, inosine, and hypoxanthine in the rat brain in vivo after intracerebral (intraventricular) and intraperitoneal administration of adenosine. Intracerebral as well as extracerebral adenosine injection caused a dose- and time-dependent increase of the cerebral acetylcholine level, which was not accompanied by an equal development of the contents of adenine compounds and their degradation products. However, a considerable turnover of adenosine was observed in the brain after both routes of administration concerning the nucleotide as well as the degradation pathway.

Partial trisomy 2q and familial translocation t(2;12)(q31;q24).

Report is given of a boy with trisomy of the distal part of the long arm of chromosome 2 (q31 leads to ter) due to a balanced 2/12 translocation in the mother: 46,XX,t(2;12) (q31;q24). Other phenotypically normal carriers of this balanced translocation are the patients sister and grandfather. The patient shows a variety of dysplastic signs mainly of the face.

Adenocarcinoma of the colon and rectum in young adults.

A retrospective analysis was made in 47 young adults (20 to 40 years of age) with adenocarcinoma of the colon and rectum. Rectal bleeding was the most frequent presenting symptom. Tumor grade had no correlation with survivial.

Salivary gland carcinoma of the palate.

Results of a detailed study of the clinical features, histology, management, and prognosis of palatal carcinoma of salivary origin in 30 patients are presented. These were compared to a larger series of salivary carcinoma at other sites, and to the known behavior of epidermoid carcinoma of the palate. The prognosis was significantly better for lesions of the palate.

Breast cancer report.

The recent increased public awareness of the necessity for early diagnosis of breast cancer has been accentuated by an intense exposure by the news media centering about the disease. This publicity includes the unfortunate but timely clinical sources of the wives of the President and the Vice President of the United States, Mrs. G.

[Dose-effect study on the bronchospasmolytic drug ipratropium bromide in relation to blood gases and hemodynamics].

In 9 patients with chronic bronchitis and cor puomonale and in one patient with vascularly pulmonary hypertension the efficiency of 0,04 mug and 0,16 mug Sch 1000 (isopropylatropin,), applicated with metered dose inhaler referring to blood gases and hemodynamics was examined. Inhalation of drug was not followed by any variations either referring to hemodynamic parameters (pulmonary pressure, systemic blood pressure, cardiac output, peripheral resistance) nor to the blood gases. After a dosage as high as eigth time as normal side effects were not found.

[Out-patient treatment and prognosis schizophrenic patients after first hospitalization (author's transl)].

99 schizophrenic patients from the General Mental Hospital in Göttingen who had received hospital treatment for the first time, where, after their discharge from hospital, studied for a period of 1 1/2 to 4 1/2 years. Information was collected with regard to the further progress of the disease on the one hand, and the response to drugs used in treatment on the other. Less than half the patients who had suffered from the disease from several years without receiving any out-patient treatment could not be helped or cured by the following hospital treatment.

[Investigations into the relationship of cell susceptibility and antibody formation and its importance in the pathogenesis of avian leukosis].

Crossbred progeny from matings of Leghorn males (lines M and G), predominantly susceptible to leukosis infection, and females from a predominantly leukosis-resistant line (line R) showed a high incidence of mortality from spontaneous leukosis. Immunological tests revealed that this field infection was caused by a subgroup A leukosis virus. Tests for susceptibility to infection and presence of RSV antibodies in embryos and pullets respectively of lines R, G and M yielded the following results: line R appears to be predominantly resistant to BH-RSV (RAV1) and BH-RSV (RAV2) (subgroups A and B), line G predominantly resistant to BH-RSV (RAV2) (subgroup B), but susceptible to BH-RSV (RAV1 ) (subgroup A), while line M is predominantly susceptible to both BH-RSV (RAV1 ) and BH-RSV (RAV2) (subgroups A and B).