Second order and transverse flow visualization through three-dimensional particle image velocimetry in millimetric ducts.

Despite recent advances in 3D particle image velocimetry (PIV), challenges remain in measuring small-scale 3D flows, in particular flows with large dynamic range. This study presents a scanning 3D-PIV system tailored for oscillatory flows, capable of resolving transverse flows less than a percent of the axial flow amplitude. The system was applied to visualize transverse flows in millimetric straight, toroidal, and twisted ducts.

The association between anxiety and depression symptoms and pain and function in adolescents and young adults with chronic pain: A meta-analysis.

Objective: Chronic pain in adolescents and young adults (AYAs) is associated with adverse functional and psychological outcomes; however, inconsistent findings across studies necessitate a comprehensive synthesis. This meta-analysis aimed to quantify associations between anxiety, depression, and pain/functional outcomes, and explore study and sample moderators, such as age, sex, pain duration, recruitment setting, and measurement tools.

Methods: We searched MEDLINE, PsycINFO, CENTRAL, and Embase through May 2024.

Anxiety and Depression in Youth With Chronic Pain: A Systematic Review and Meta-Analysis.

Importance: For youth with chronic pain, anxiety and depression are reported as consequences of experiencing pain and maintaining factors of ongoing pain and disability. However, prevalence estimates of anxiety and depression remain unclear.

Objective: To report the prevalence of clinical anxiety and depression for youth with chronic pain and compare symptoms of anxiety and depression between youth with and without chronic pain.

Transverse flow under oscillating stimulation in helical square ducts with cochlea-like geometrical curvature and torsion.

The cochlea, situated within the inner ear, is a spiral-shaped, liquid-filled organ responsible for hearing. The physiological significance of its shape remains uncertain. Previous research has scarcely addressed the occurrence of transverse flow within the cochlea, particularly in relation to its unique shape.

Internet-Delivered Psychological Pain-Management for Young Adults With Chronic Pain: An Investigation of Clinical Trial Data.

Young adults report chronic pain at rates of around 12% but lack access to clinical services. There is interest in learning how this emerging adult population engages with and responds to treatment. Using data from young adults aged 18 to 30 years (M = 25.

Wall Shear Stress and Pressure Fluctuations under Oscillating Stimulation in Helical Square Ducts with Cochlea-like Geometrical Curvature and Torsion.

Our study aims to provide basic insights on the impact of the spiral shape of the cochlea, i.e., of geometric torsion and curvature, on wall pressure and wall shear stress.

Deep Multi-Scale Feature Learning for Defocus Blur Estimation.

This paper presents an edge-based defocus blur estimation method from a single defocused image. We first distinguish edges that lie at depth discontinuities (called depth edges, for which the blur estimate is ambiguous) from edges that lie at approximately constant depth regions (called pattern edges, for which the blur estimate is well-defined). Then, we estimate the defocus blur amount at pattern edges only, and explore an interpolation scheme based on guided filters that prevents data propagation across the detected depth edges to obtain a dense blur map with well-defined object boundaries.

The novel therapeutic potential of bovine α-lactalbumin made lethal to tumour cells (BALMET) and oleic acid in oral squamous cell carcinoma (OSCC).

Background: Since the serendipitous discovery of bovine α-lactalbumin made lethal to tumour cells (BAMLET)/human α-lactalbumin made lethal to tumour cells there has been an increased interest in the ability of the two components, oleic acid and α-lactalbumin, to form anti-cancer complexes. Here we have investigated the in-vitro efficacy of the BAMLET complex in killing oral cancer (OC) cells, determined the active component of the complex and investigated possible biological mechanisms.

Materials And Methods: Two OC cell lines (±p53 mutation) and one dysplastic cell line were used as a model of progressive oral carcinogenesis.

Estimation of a priori signal-to-noise ratio using neurograms for speech enhancement.

In statistical-based speech enhancement algorithms, the a priori signal-to-noise ratio (SNR) must be estimated to calculate the required spectral gain function. This paper proposes a method to improve this estimation using features derived from the neural responses of the auditory-nerve (AN) system. The neural responses, interpreted as a neurogram (NG), are simulated for noisy speech using a computational model of the AN system with a range of characteristic frequencies (CFs).

How does drinking water affect attention and memory? The effect of mouth rinsing and mouth drying on children's performance.

There is general consensus that drinking water facilitates certain cognitive processes. However, it is not yet known what mechanism underlies the effect of drinking on performance and these may be different for different cognitive processes. We sought to elucidate the mechanisms involved by establishing at what stage of the drinking process cognitive performance is influenced.

Measuring vocal difference in bird population pairs.

Over time, a bird population's acoustic and morphological features can diverge from the parent species. A quantitative measure of difference between two populations of species/subspecies is extremely useful to zoologists. Work in this paper takes a dialect difference system first developed for speech and refines it to automatically measure vocalisation difference between bird populations by extracting pitch contours.

Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms.

Despite significant advances, the molecular identity of the cytotoxic species populated during in vivo amyloid formation crucial for the understanding of neurodegenerative disorders is yet to be revealed. In this study lysozyme prefibrillar oligomers and fibrils in both mature and sonicated states have been isolated through an optimized ultrafiltration/ultracentrifugation method and characterized with various optical spectroscopic techniques, atomic force microscopy, and transmission electron microscopy. We examined their level and mode of toxicity on rat pheochromocytoma (PC12) cells in both differentiated and undifferentiated states.

ViSQOLAudio: An objective audio quality metric for low bitrate codecs.

Streaming services seek to optimise their use of bandwidth across audio and visual channels to maximise the quality of experience for users. This letter evaluates whether objective quality metrics can predict the audio quality for music encoded at low bitrates by comparing objective predictions with results from listener tests. Three objective metrics were benchmarked: PEAQ, POLQA, and VISQOLAudio.

Alternatively folded proteins with unexpected beneficial functions.

HAMLET (human α-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.

Electrostatic interactions play an essential role in the binding of oleic acid with α-lactalbumin in the HAMLET-like complex: a study using charge-specific chemical modifications.

Human α-lactalbumin made lethal to tumor cells (HAMLET) and its analogs are partially unfolded protein-oleic acid (OA) complexes that exhibit selective tumoricidal activity normally absent in the native protein itself. To understand the nature of the interaction between protein and OA moieties, charge-specific chemical modifications of lysine side chains involving citraconylation, acetylation, and guanidination were employed and the biophysical and biological properties were probed. Upon converting the original positively-charged lysine residues to negatively-charged citraconyl or neutral acetyl groups, the binding of OA to protein was eliminated, as were any cytotoxic activities towards osteosarcoma cells.

Simulated performance intensity functions.

Measuring speech intelligibility for different hearing aid fitting methods in a simulated environment would allow rapid prototyping and early design assessment. A simulated performance intensity function (SPIF) test methodology has been developed to allow experimentation using an auditory nerve model to predict listeners' phoneme recognition. The test discriminates between normal hearing and progressively degrading levels of sensorineural hearing loss.

Algorithms for the digital restoration of torn films.

This paper presents algorithms for the digital restoration of films damaged by tear. As well as causing local image data loss, a tear results in a noticeable relative shift in the frame between the regions at either side of the tear boundary. This paper describes a method for delineating the tear boundary and for correcting the displacement.

Impact of gastrointestinal problems on adherence to low-dose acetylsalicylic Acid: a quantitative study in patients with cardiovascular risk.

Background: Low-dose acetylsalicylic acid (ASA; 75-325 mg) is a mainstay of therapy for patients at high risk of cardiovascular (CV) events. However, in some patients, such treatment is associated with upper gastrointestinal (GI) adverse effects, e.g.

InterProScan: protein domains identifier.

InterProScan [E. M. Zdobnov and R.

The EMBL Nucleotide Sequence Database.

The EMBL Nucleotide Sequence Database (http://www.ebi.ac.

InterPro, progress and status in 2005.

InterPro, an integrated documentation resource of protein families, domains and functional sites, was created to integrate the major protein signature databases. Currently, it includes PROSITE, Pfam, PRINTS, ProDom, SMART, TIGRFAMs, PIRSF and SUPERFAMILY. Signatures are manually integrated into InterPro entries that are curated to provide biological and functional information.

Public web-based services from the European Bioinformatics Institute.

The mission of the European Bioinformatics Institute (EBI), an outstation of the European Molecular Biology Laboratory (EMBL) in Heidelberg, is to ensure that the growing body of information from molecular biology and genome research is placed in the public domain and is accessible freely to all parts of the scientific community in ways that promote scientific progress. To fulfil this mission, the EBI provides a wide variety of free, publicly available bioinformatics services. These can be divided into data submissions processing; access to query, analysis and retrieval systems and tools; ftp downloads of software and databases; training and education and user support.

Public services from the European Bioinformatics Institute.

The European Bioinformatics Institute (EBI) provides numerous free-of-charge, publicly available bioinformatics services that can be divided into the following categories: ftp downloads; data submissions processing and biological database production; access to query; analysis and retrieval systems and tools; user support; training and education and industry support through EBI's SME program. These services are all available at the website. It is imperative that EBI's data as well as the tools to analyse it efficiently are made available in a free and unambiguous way to the scientific community.

The Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology.

The Gene Ontology Annotation (GOA) database (http://www.ebi.ac.

The EMBL Nucleotide Sequence Database.

The EMBL Nucleotide Sequence Database (http://www.ebi.ac.