Publications by authors named "Harshithkumar R"
Article Synopsis
- AR, an Ayurvedic botanical, was studied for its effects on HIV-1 replication and its ability to reduce mitochondrial dysfunction during infection.
- Both AR root extracts and its main active compound, Shatavarin IV, showed non-toxic, dose-dependent inhibition of HIV-1 in laboratory tests, particularly effective against certain viral subtypes.
- Shatavarin IV interacted with key enzymes involved in HIV-1 replication, suggesting its potential as a therapeutic agent, while also helping to alleviate mitochondrial damage caused by the virus.
Article Synopsis
- Reactive oxygen species (ROS) are important signaling molecules in cells but can cause oxidative stress (OS) when levels are too high, which is linked to HIV infection and related health issues.
- The review paper explores how ROS are generated during HIV infections, particularly focusing on the viral protein Tat and its role in increasing ROS levels, alongside other viral proteins and antiretroviral therapies.
- The study suggests that since ROS are involved in various health problems for HIV patients, antioxidant therapy could be a promising treatment, but more research is needed to find new ways to reduce the harmful effects associated with oxidative stress from treatment.
Background: Several anti-retroviral drugs are available against Human immunodeficiency virus type-1, but have multiple adverse side effects. Hence, there is an incessant compulsion for effectual anti-retroviral agents with minimal or no intricacy. Traditionally, natural products have been the most successful source for the development of new medications.
View Article and Find Full Text PDFHPV, or Human Papilloma Virus, has been the primary causative agent of genital warts and cervical cancer worldwide. It is a sexually transmitted infection mainly affecting women of reproductive age group, also infecting men and high-risk group individuals globally, resulting in high mortality. In recent years, HPV has also been found to be the major culprit behind anogenital cancers in both gender and oropharyngeal and colorectal cancers.
View Article and Find Full Text PDFAntiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects. Thus, there is a continuous need to explore safe and efficacious anti-retroviral agents. Carica papaya Linn and Psidium guajava are known for their various biological activities.
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