Infections in Standard or Tapered Dose of Prednisolone for Alcohol-Associated Hepatitis: A Randomized Trial (STASH Trial).

Objectives: Current guidance recommends a 40-mg dose of prednisolone (or equivalent) for severe alcohol-associated hepatitis (AAH), while infections are not uncommon in them. The benefits of a rapid prednisolone tapering regimen in mitigating infection in patients with AAH are unknown. The primary objective was to assess the incidence of infection by day 90.

Kaposi's sarcoma unmasked by corticosteroids in an advanced HIV patient with tuberculosis immune reconstitution inflammatory syndrome.

In this case report, we present a 35-year-old homosexual man with advanced HIV disease and disseminated tuberculosis (TB) who developed paradoxical TB immune reconstitution inflammatory syndrome (IRIS). Corticosteroids, vital in life-threatening IRIS, were initiated, resulting in symptom resolution but unmasking AIDS-associated Kaposi's sarcoma (KS). Diagnostic confirmation revealed disseminated KS, necessitating a comprehensive therapeutic strategy involving chemotherapy and thalidomide as a steroid-sparing agent.

Hydroxychloroquine pre-exposure prophylaxis for COVID-19 among healthcare workers: Initial experience from India.

Background: Hydroxychloroquine (HCQ) had generated considerable interest for coronavirus disease 2019 (COVID-19) prophylaxis. We conducted a prospective observational study at a tertiary care hospital in India, with dedicated COVID-19 care facilities.

Objectives: Primary objective was incidence of adverse effects, secondary objective being efficacy in preventing COVID-19.

Seroprevalence and attainment of herd immunity against SARS CoV-2: A modelling study.

Objective: The present study aims to predict the likelihood of and likely time required to attain herd immunity against COVID-19 in New Delhi due to natural infection.

Method: An ODE-based mathematical model was constructed by extending the classical SEIR model to predict the seroprevalence rate. We estimated the parameter values for Delhi using available data (reported cases and the seroprevalence rate) and used them for future prediction.