ZEB2 signaling is essential for ureteral smooth muscle cell differentiation and maintenance.

Unlabelled: Mowat-Wilson Syndrome (MWS) is a multiple congenital anomaly syndrome caused by mutations in the which plays a critical role in cell fate determination and differentiation during development. Congenital anomalies of the kidney and urinary tract (CAKUT) have been reported in MWS patients. However, the role of ZEB2 in urinary tract development and the cellular and molecular mechanism underlining the CAKUT phenotypes in MWS remains unknown.