Publications by authors named "Harshita Mehrotra"
Background: Cold agglutinin disease (CAD) is relatively rare and has primarily been reported as retrospective case series.
Aim: We reviewed our experience with CAD to shed light on this disease.
Study Settings And Design: This was a retrospective review of all patients with CAD managed at our institution between 2007 and 2018.
Article Synopsis
- The study focused on identifying predictors of massive blood transfusion during orthotopic liver transplantation (OLT) to aid in better blood bank management.
- Data was analyzed from 970 patients who underwent OLT between 2007 and 2017, highlighting that 12.3% experienced massive transfusions defined as receiving 10 or more units of packed red blood cells.
- Key predictors of massive transfusion included factors like previous abdominal surgery, the patient’s hemoglobin level, MELD score, and the times related to cold and warm ischemia as well as overall operation duration.
Article Synopsis
- * In a study analyzing 226 cases of breast cancer using the 2018 ASCO-CAP guidelines, researchers identified subgroups of HER2 amplification and found that higher amplification levels corresponded to better overall survival (OS) and disease-free survival (DFS).
- * The findings indicate that excessive HER2 amplification is linked to longer survival times, suggesting the importance of precise HER2 classification in predicting treatment outcomes for breast cancer patients.
Article Synopsis
- Unconventional T-lymphocyte populations, specifically innate αβ T cells (iαβTs), play a significant role in regulating tumor immunity, particularly in pancreatic ductal adenocarcinoma (PDA).
- iαβTs make up around 10% of T lymphocytes in PDA and have unique T-cell receptor profiles and immunogenic characteristics compared to other lymphocytes.
- The study demonstrates that iαβT cells not only help slow tumor growth through adoptive transfer in both mouse and human models but also promote the activation and expansion of other immune cells, marking them as promising targets for immunotherapy.
Background: Anemia in pregnant women, a significant cause of maternal and infant mortality and morbidity, has not been adequately studied in the population of Andaman and Nicobar Islands. In this regard, the study was conducted to document the prevalence and severity of anemia and its associated sociodemographic factors in pregnant women in Andaman and Nicobar Islands.
Methods: The cross-sectional study was carried out at the Department of Obstetrics and Gynecology at G.