Publications by authors named "Harshita Annappa"
Curr Microbiol
February 2024
Article Synopsis
- Uncouplers of oxidative phosphorylation disrupt the proton gradient in bacteria, leading to reduced ATP production and stress response adaptations.
- In a study of E. coli, researchers analyzed how different uncouplers (CCCP, DNP, NaSal) affected the expression of genes linked to antibiotic resistance, finding that NaSal and DNP induced resistance genes while CCCP did not.
- The study revealed that the Lon protease plays a crucial role in the bacteria's response to uncouplers, with a lon-deficient strain exhibiting altered growth and resistance patterns, highlighting concerns about the environmental impact of uncouplers on antibiotic resistance.
