Investigations of chemical compositions and antioxidative potential of essential oils isolated from the leaves of two species.

and are Sri Lankan endemic plants with significant therapeutic potential and numerous health-care applications. Despite this, there are no adequate literatures reported on the chemical compositions (CCs) and antioxidative potential (AP) of leaves' essential oils (EOs). The purpose of this study was to extract EOs from the leaves and investigate the CCs and AP of the extracted EOs.

Sesquiterpenes and monoterpenes from different varieties of guava leaf essential oils and their antioxidant potential.

Despite that Sri Lanka is a biodiversity hotspot with numerous guava varieties ( L.), no adequate scientific research has been reported on leaf essential oil (EO) composition based on varieties and its pharmacological properties, namely antioxidant properties. Therefore, this study focused to evaluate the chemical compositions and antioxidative capacity of EOs isolated from leaves of seven guava varieties grown in Sri Lanka, including apple-guava ( PGA), common-guava ( PGCG), two wild-guava; cultivar of (PGG) and a cultivar of (PGE), two introduced varieties of (PGK and PGP), and one introduced variety of (PGC).

Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells.

The structure of novel binary nanosponges consisting of (cholesterol-(K/D) DEVDGC)-trimaleimide units possessing a trigonal maleimide linker, to which either lysine (K) or aspartic acid (D) are tethered, has been elucidated by means of TEM. A high degree of agreement between these findings and structure predictions through explicit solvent and then coarse-grained molecular dynamics (MD) simulations has been found. Based on the nanosponges' structure and dynamics, caspase-6 mediated release of the model drug 5(6)-carboxyfluorescein has been demonstrated.

Nanoplatforms for highly sensitive fluorescence detection of cancer-related proteases.

Numerous proteases are known to be necessary for cancer development and progression including matrix metalloproteinases (MMPs), tissue serine proteases, and cathepsins. The goal of this research is to develop an Fe/Fe3O4 nanoparticle-based system for clinical diagnostics, which has the potential to measure the activity of cancer-associated proteases in biospecimens. Nanoparticle-based "light switches" for measuring protease activity consist of fluorescent cyanine dyes and porphyrins that are attached to Fe/Fe3O4 nanoparticles via consensus sequences.