Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery.

Background: Encapsulation of hydrophilic drugs within liposomes can be challenging.

Methods: A novel chitosan derivative, O-palmitoyl chitosan (OPC) was synthesized from chitosan and palmitoyl chloride using methane-sulfonic acid as a solvent. The success of synthesis was confirmed by Fourier transform infra-red (FT-IR) spectroscopy and proton NMR spectroscopy (H-NMR).