Intranasal nanoparticulate delivery systems for neurodegenerative disorders: a review.

Neurodegenerative diseases are a significant cause of mortality worldwide, and the blood-brain barrier (BBB) poses a significant challenge for drug delivery. An intranasal route is a prominent approach among the various methods to bypass the BBB. There are different pathways involved in intranasal drug delivery.

Dynamic correction of ulnar claw hand deformity with a simple insertion into the lumbrical muscle.

Numerous methods of tendon transfers are available to correct claw hand deformity. In this article, we describe a simple insertion of the transferred flexor digitorum superficialis tendon, into the lumbrical muscle and proximal tendon. Sixty patients underwent surgery for claw hand correction.

Recurrent Trigeminal Neuralgia: A Case Series and a Review of the Literature.

Trigeminal neuralgia is a peripheral neuropathy characterized by intermittent episodes of severe facial pain originating in the sensory nucleus of the trigeminal nerve. The most commonly involved area is the mandibular division with a higher prevalence on the right side. Advances in the field of MRI have played an important role in its diagnosis, especially in presurgical assessment, to probe into any secondary causes of nerve compression and/or neurovascular conflict.

Autologous Fat Grafting with or without Processing: A Study in an Indian Clinical Context.

Background: Although fat grafting has become an attractive method of correction of soft tissue deficiencies, variability in results exists. As the understanding of mechanism of survival of graft improves, the concepts regarding fat grafting change. There are many ways to process the aspirated fat with no clear method superior.

The Unusual Impalement Injuries of the Hand.

Impalement injuries are relatively rare. The most common anatomical site of involvement is the extremities. Impalement injuries are defined as penetrating injuries where traumatic agent remains impaled in the human body.

Epidemiological Profile of Femoral Head Osteonecrosis in the North Indian Population.

Background: There are limited studies on the epidemiology of femoral head osteonecrosis in Indian population. This study was designed to look for the risk factors of osteonecrosis hip and to assess the severity as per radiological staging (Association Research Circulation Osseous [ARCO]) and clinical score (Harris hip score [HHS]).

Materials And Methods: 249 patients (382 hips) of osteonecrosis femoral head (ONFH) who were evaluated at our center between January 1, 2005, and June 30, 2013, were included in this retrospective study.

Sample preparation method considerations for integrated transcriptomic and proteomic analysis of tumors.

Sample processing protocols that enable compatible recovery of differentially expressed transcripts and proteins are necessary for integration of the multiomics data applied in the analysis of tumors. In this pilot study, we compared two different isolation methods for extracting RNA and protein from laryngopharyngeal tumor tissues and the corresponding adjacent normal sections. In Method 1, RNA and protein were isolated from a single tissue section sequentially and in Method 2, the extraction was carried out using two different sections and two independent and parallel protocols for RNA and protein.

Efficacy of Epidural Perineural Injection of Autologous Conditioned Serum in Unilateral Cervical Radiculopathy: A Pilot Study.

Study Design: Prospective randomized pilot study.

Objective: Evaluation of the efficacy of epidural perineural injection of autologous conditioned serum (ACS) versus methylprednisone (MPS) in unilateral cervical radiculopathy patients.

Summary Of Background Data: Cervical radiculopathy is often treated by nonoperative and operative means.

Free medial plantar artery flap for the reconstruction of great toe pulp.

The great toe is an important body structure both functionally and cosmetically. The defect over the great toe is very challenging to treat. Our patient was a 9-year-old boy, presenting with posttraumatic loss of partial right great toe pulp.

Asymptomatic obese hypertensives and need of routine echocardiography for left ventricular mass assessment and treatment.

Background: Echocardiographic determination of Left Ventricle Mass (LVM) - an important marker of cardiovascular disease, has been given a lot of importance in clinical diagnosis and in planning of treatment. Clinically asymptomatic compensated hypertensives show some pathological findings which are indicative of left ventricular dysfunction.

Methods: The study population of 106 males, after a detailed clinical examination, were evaluated by echocardiography and were classified as per the body mass index classification of WHO Western Pacific Region in 2000 for Asian population.

Prevalence of nutrient canals in diabetes mellitus and hypertension: A radiographic study.

Aim: The present study is undertaken primarily to determine if a correlation in the appearance of nutrient canals with hypertension and diabetes exists and to determine whether the presence of nutrient canals can be used as a clue for the detection of hypertensive and diabetic patients.

Patients And Methods: A total of 300 subjects were selected from the out-patient department comprising of 100 diabetic patients, 100 hypertensive patients and 100 patients without any systemic diseases as control group. Intraoral periapical radiograph of all these patients were taken for evaluation.

Familial Crouzon syndrome.

Crouzon syndrome is an autosomal dominant condition of the craniosynostotic syndromes without syndactyly and with various dentofacial anomalies. Craniosynostosis, maxillary hypoplasia, shallow orbits, ocular proptosis and hypertelorism are the characteristic features of Crouzon syndrome. This report describes the variable clinical features in affected individuals over two generations of a family with dentofacial deformities and review of literature.

Bird-headed dwarf of Seckel.

Seckel syndrome is an extremely rare inherited disorder characterized by growth delays prior to birth resulting in low birth weight. Growth delays continue after birth resulting in short stature (dwarfism). This syndrome is associated with an abnormally small head, varying degrees of mental retardation and unusual "beak like" protrusion of nose.

Florid cemento-osseous dysplasia.

Cemento-osseous dysplasia is probably the most common fibro-osseous lesion encountered in clinical practice. It is thought to be a reactive phenomenon that arises from elements within the periodontal ligament. Here we present a case of 37-year-old female patient, who reported for a regular dental check-up.