Comparative Analysis of Displacements and Stress Produced by Square and Rectangular Bracket Slot With Incremental Torque: A Finite Element Analysis Study.

Introduction: This study aimed to perform a comparative analysis of stresses and displacements with incremental torque on the maxillary incisors and surrounding cortical bone using conventional metal brackets with rectangular slots and passive self-ligating brackets with square slots using finite element analysis (FEA).

Materials And Methods: An in vitro FEA study was conducted, in which a three-dimensional (3D) model of the maxilla was built using ANSYS software version 18 (ANSYS Inc., Canonsburg, PA).

Impact of Migraine on Family Members - A Cross-sectional Study in Southern Part of India.

Background: Migraine is a disabling primary headache disorder characterized by recurrent episodes of headache. Migraine not only imposes a burden on the sufferer but also imposes a burden on their family members too. A holistic approach is more essential in the management of migraine and family members should also be included in the management of migraine.

Covalently bonded interface in polymer/boron nitride nanosheet composite toward enhanced mechanical and thermal behaviour.

This experimental study aimed to enhance the mechanical and thermal properties of BN (hexagonal boron nitride) nanosheet-reinforced high-density polyethylene by functionalizing its interface. The challenges associated with this nanocomposites are its poor dispersion and weak interface. Accordingly, to improve the load transfer at the interface, BN nanosheets were chemically modified with silane functional groups ((3-aminopropyl)tri-ethoxy silane), making it possible to form covalent bonds between the maleic anhydride-grafted polyethylene and nanosheet.

Stearyl palmitate a multi-target inhibitor against breast cancer: in-silico, in-vitro & in-vivo approach.

Multi-target inhibitors are currently trending in the pharmaceutical research, as they possess increased efficacy and reduced toxicity. In this study multi-target inhibitors for breast cancer are explored from a curated list of natural products, i.e.

Effect of focusing element-induced aberrations on filamentation and supercontinuum emission in ambient air.

Femtosecond laser pulse induced filamentation in atmosphere is susceptible to a number of input laser, focusing optics and medium characteristics. Filamentation of fs pulses in atmosphere is an intense propagation regime where the focusing geometry used to focus the fs laser pulses play an important role influencing the filament intensity and the associated supercontinuum. We identified different optical elements used for focusing the fs laser pulses leading to filamentation in air and classified them according to the induced aberrations.

Spatio-temporal characterization of ablative Cu plasma produced by femtosecond filaments.

We present the spatial and temporal characterization of the copper (Cu) plasma produced by the femtosecond laser filaments. The filaments of various lengths and intensities were generated with the aid of three different focusing lenses. Further, the filamentation induced breakdown spectroscopy (FIBS) measurements were carried out for each filament at three different positions along the length of the filament.

Supercontinuum generation from zinc borate glasses: bandgap versus rare-earth doping.

We report an enhanced supercontinuum generation (SCG) from a rare-earth () doped low bandgap zinc borate glass when excited with 60 fs pulses from a Ti-sapphire laser. The emission associated with the absorption bands due to doping (around 420-500 and 580-600 nm) is observed to assist the enhanced SCG.

Erectile Dysfunction in Migraine in Indian Patients.

Background: Migraine is one of the common causes of primary headache worldwide. Migraine headaches significantly affect family and social activities. Migraine also impacts the sexual function of the sufferers.

The assessment of Hair Transplantation Outcomes in Cicatricial Alopecia.

Background: Cicatricial alopecia (CA) is scarring alopecia due to a diverse group of disorders which destroy the hair follicle, replace it with scar tissue causing permanent hair loss. Spontaneous regrowth of hair in CA is rarely seen and thus it has a negative impact on the self-esteem of the patient. However, hair transplantation (HT) has emerged as an effective modality of treatment to replace lost hair for cosmetic benefit.

Subjective discomfort analysis of human body in semi-supine posture caused by vertical sinusoidal vibration.

The vibration discomfort to the human body in semi-supine posture is currently evaluated as per ISO 2631-1, although it is recommended for sitting, standing and recumbent posture. The present study investigated the frequency-dependence of subjective responses of semi-supine humans to vertical vibration (0.5-1.

Migraine Disability, Quality of Life, and Its Predictors.

Migraine is the most disabling primary headache and is the second most prevalent primary headache affecting middle-aged females more. However, diagnosis and treatment of migraine persists to be inadequate. Despite being a major cause of disability, works done to understand the burden and impact of migraine on daily living remains sparse.

Assessment of Alteration of Serum Adiponectin Levels in Migraineurs: An Interventional Case Control Study.

Background And Objectives: Migraine is one of the major headache disorders. Epidemiological studies have shown its high prevalence and negative impact on personal and socioeconomic aspects. It is currently ranked 19th by the "World Health Organization" amongst all diseases, leading to disability worldwide.

Design, Synthesis, Evaluation of Antimicrobial Activity and Docking Studies of New Thiazole-based Chalcones.

Background: Thiazole derivates as well as chalcones, are very important scaffold for medicinal chemistry. Literature survey revealed that they possess wide spectrum of biological activities among which are anti-inflammatory and antimicrobial.

Objectives: The current studies describe the synthesis and evaluation of antimicrobial activity of twenty eight novel thiazole-based chalcones.

Response of localized, resistant, tingling vitiligo to pregabalin: A case report.

Vitiligo is a common depigmenting disease with complex pathogenesis. One of the proposed pathogenesis is the neural hypothesis, which suggests an altered reaction to neuropeptides, catecholamines, and their metabolites affecting melanocytes. Here, we report a case of 26-year-old female patient, whose vitiligo patches were associated with unusual crawling and tingling sensation and responded to a clinical trial of pregabalin.

Synthesis and Structural Elucidation of Novel Benzothiazole Derivatives as Anti-tubercular Agents: In-silico Screening for Possible Target Identification.

Background: Benzothiazole derivatives are known for anti-TB properties. Based on the known anti-TB benzothiazole pharmacophore, in the present study, we described the synthesis, structural elucidation, and anti-tubercular screening of a series of novel benzothiazole (BNTZ) derivatives (BNTZ 1-7 and BNTZ 8-13).

Objective: The study aims to carry out the development of benzothiazole based anti-TB compounds.

Benzothiazole analogs as potential anti-TB agents: computational input and molecular dynamics.

Biotin is very important for the survival of Mycobacterium tuberculosis. 7,8-Diamino pelargonic acid aminotransaminase (DAPA) is a transaminase enzyme involved in the biosynthesis of biotin. The benzothiazole title compounds were investigated for their in vitro anti-tubercular activity against two tubercular strains: H37Rv (ATCC 25,177) and MDR-MTB (multidrug-resistant M.

New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation.

Background: Thiazole and benzothiazole derivatives, as well as thiazolidinones are very important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide spectrum of biological activities including antimicrobial activity.

Objective: The goal of this paper is the designing of new benzothiazole based thiazolidinones and the evaluation of their biological activities.

(Linn.)-mediated green silver nanoparticles trigger caspase 9-dependent cell death in MCF7 and MDA-MB-231 cells.

Introduction: Leaf extract of or mint plant was used as reducing agent for the synthesis of green silver nanoparticles (GSNPs) as a cost-effective, eco-friendly process compared to that of chemical synthesis. The existence of nanoparticles was characterized by ultraviolet-visible spectrophotometry, dynamic light scattering, Fourier transform infrared spectroscopy, X-ray diffraction, energy-dispersive X-ray analysis, atomic-force microscopy and transmission electron microscopy analyses, which ascertained the formation of spherical GSNPs with a size range of 3-9 nm. Anticancer activities against breast cancer cell lines (MCF7 and MDA-MB-231) were studied and compared with those of chemically synthesized (sodium borohydride [NaBH]-mediated) silver nanoparticles (CSNPs).

An elderly male with tingly legs and a heavy heart: Persisting with the diagnosis!

Pursuing a diagnosis despite a negative nerve biopsy report requires a strong clinical conviction. Paying attention to clinical details and a diligent review of medical records is needed to solve cases in which the diagnosis is not obvious despite numerous tests. We present once such case of an elderly man with chronic diarrhea, weight loss, and peripheral neuropathy and elaborate on a step by step basis on how the clinical thought process evolved after sifting through the reports of scan and tests done during his work up.

Development and evaluation of buccal films impregnated with selegiline-loaded nanospheres.

Poor peroral therapeutic efficiency of selegiline is primarily due to the extensive hepatic metabolism and hence the need for an alternative route of administration. The present study is based on evaluation of a buccal film which is impregnated with selegiline nanospheres to enhance the systemic bioavailability. Selegiline-loaded nanospheres prepared using poly(lactide-co-glycolide) was embedded into buccal films (F-F) with varying polymer composition [hydroxypropyl methylcellulose and eudragit].

Design, synthesis, and characterization of (1-(4-aryl)- 1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis.

The novel (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were synthesized by the click reaction of the dihydropyrimidinones, bearing a terminal alkynyl group, with various substituted aryl azides at room temperature using a catalytic amount of Cu(OAc)2 and sodium ascorbate in a 1:2 ratio of acetone and water as a solvent. The newly synthesized compounds were characterized by a number of spectroscopic techniques, such as infrared, liquid chromatography-mass spectrometry, (1)H, and (13)C nuclear magnetic resonance along with single crystal X-ray diffraction. The current procedure for the synthesis of 1,2,3-triazole hybrids with dihydropyrimidinones is appropriate for the synthesis of a library of analogs 7a-l and the method accessible here is operationally simple and has excellent yields.

The Extensor Indicis Brevis - A Rare Variation and its Significance.

Variations in muscle attachments are valuable in interpreting rare clinical conditions. This case report discusses about the abnormal extensor indicis muscle attachment in left hand of male cadaver and its clinical relevance. The extensor indicis muscle was arising from lunate carpal bone and posterior radiocarpal ligament which further continued as short belly and had its distal attachment on the proximal phalanx of the index finger.

SNAPPE-II (Score for Neonatal Acute Physiology with Perinatal Extension-II) in Predicting Mortality and Morbidity in NICU.

Introduction: A number of illness severity scores have evolved which would predict mortality and morbidity in intensive care units. One such scoring system developed by Richardson was SNAPPE-II (Score for Neonatal Acute Physiology with Perinatal extension-II).

Aim: The present study was conducted to assess the validity of SNAPPE-II score as a predictor of mortality and morbidity.