Background Diabetic foot ulcers (DFUs) are prevalent complications of diabetes mellitus, often leading to severe infections and adverse clinical outcomes. , a gram-negative bacterium, has emerged as a significant causative agent in DFU infections, raising concerns due to its increasing antibiotic resistance, particularly in extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL) production. Aim This study aimed to comprehensively assess the prevalence, antibiotic resistance profiles, and clinical correlates of ESBL- and MBL-producing isolates specifically derived from DFUs.
View Article and Find Full Text PDFBackground Diabetic foot ulcers (DFUs) are a significant complication of diabetes mellitus and are often accompanied by various complications including hemolytic anemia. However, the clinical and hematological correlates of hemolytic anemia in patients with DFU remain poorly understood. This prospective observational study aimed to investigate the clinical and hematological correlates of hemolytic anemia in patients with DFU and to elucidate the potential mechanisms underlying this complication and its impact on wound healing.
View Article and Find Full Text PDFAmong numerous biologically important metal cations, strontium (Sr) has received much attention in bone tissue regeneration because of its osteoinductive properties combined with its ability to inhibit osteoclast activity. In this study, strontium-doped hydroxyapatite (Sr-HAp) nanorods with varying molar ratios of Ca : Sr (10 : 0, 9 : 1, 5 : 5, 3 : 7 and 0 : 10) were synthesized using the chemical precipitation technique. The synthesized Sr-HAp nanostructures were characterized using powder X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy, energy dispersive X-ray spectroscopy, and Raman and Fourier transform infrared (FTIR) spectroscopies to understand their structural and morphological features, and composition.
View Article and Find Full Text PDFBackground: Ventilator-associated pneumonia (VAP) is the most frequent Intensive Care Unit acquired infection.
Aims: The aim is to determine the incidence, bacteriology and factors affecting VAP and to determine the multi-drug resistant (MDR) pathogens.
Settings And Design: This was a prospective observational study conducted over a period of 1 year from April 1, 2011, to March 31, 2012.
Background: AIDS has become chronic illness which is well treated with antiretroviral therapy and management of opportunistic infections (OIs).
Aims And Objectives: The study clinical profile and outcome of human immunodeficiency virus (HIV) seropositive patients.
Materials And Methods: This was retrospective observational study carried out over a period of 1 year (January 2011-December 2011).
We studied the dialysis practice-patterns with regard to various aspects of chronic kidney disease (CKD) stage 5D, like anemia, mineral bone disease, vaccination, hospitalization, hypertension and cost of therapy. Four hundred and sixty-four adult hemodialysis (HD) patients from various dialysis centers of Mumbai were included in the study. The mean age of the study patients was 47.
View Article and Find Full Text PDFBackground: Recent studies have found that there is a strong association between ischemic heart disease (IHD) and hypertension (HTN) with spirometric indices.
Aims: To study the prevalence of obstructive airway disease (OAD) in non-smoker subjects with IHD and HTN and to compare them with healthy population.
Settings And Design: This was a prospective, case-control, and observational study.
Indian J Crit Care Med
October 2011
Context: Central venous catheter-related bloodstream infection (CRBSI) is associated with high rates of morbidity and mortality in critically ill patients.
Aims: This study was conducted to determine the incidence of central venous catheter-related infections (CRIs) and to identify the factors influencing it. So far, there are very few studies that have been conducted on CRBSI in the intensive care unit in India.
Background: The incidence of heart failure in diabetic subjects is high even in the absence of hypertension and coronary artery disease.
Aims: The purpose of this study was to study the incidence of diastolic dysfunction in diabetic subjects and its relation to age, duration of diabetes mellitus (DM), Glycosylated hemoglobin (HbA1c) levels, obesity indices and diabetic microangiopathies.
Settings And Design: This was a case control prospective study conducted at the teaching hospital during a one year period.
A total of 100 patients of acute pharyngitis were evaluated clinically and investigated microbiologically. Eighty patients proved culture positive acute pharyngitis, among them 17 patients proved positive for beta-haemolytic streptococci, 14 patients for Staphylococcus aureus, 24 for pneumococci, 13 patients for Streptococcus viridans, 3 for Brahmanella catarrhalis, 4 for coagulase negative staphylococci, 5 had mixed infection. Further streptococcal grouping was carried out on these isolates.
View Article and Find Full Text PDFNon-compaction cardiomyopathy is a recently recognized disorder, based on an arrest in endomyocardial morphogenesis. The disease is characterized by heart failure (both diastolic and systolic), systemic emboli and ventricular arrhythmias. The diagnosis is established by two-dimensional echocardiography.
View Article and Find Full Text PDFPericardial effusion is frequently found in patients with hypothyroidism, but it is rarely associated with cardiac tamponade. Hypothyroidism complicated by cardiac tamponade is rarely referenced in the medical literature. Here we report an unusual case of a 45-year-old female, who presented with breathlessness and was found to have hypothyroidism with large pericardial effusion with cardiac tamponade.
View Article and Find Full Text PDFLeptospirosis is an important emerging zoonosis with a worldwide distribution that is characterized by a broad spectrum of clinical manifestations ranging from inapparent infection to fulminant disease. Leptospirosis has protean clinical manifestations. The classical presentation of the disease is an acute biphasic febrile illness with or without jaundice.
View Article and Find Full Text PDFIndian J Sex Transm Dis AIDS
January 2011
Cerebral toxoplasmosis is an acquired immunodeficiency syndrome (AIDS)-related infection and is one of the causes of CNS mass lesions in AIDS. Toxoplasmosis is the most common cerebral mass lesion encountered in HIV-infected patients, and its incidence has increased markedly since the beginning of the AIDS epidemic. Cerebral toxoplasmosis is associated with high mortality and morbidity in patients with acquired immunocopromised state.
View Article and Find Full Text PDFWe describe a case of ruptured aneurysm of the left coronary sinus of Valsalva diagnosed by transthoracic two-dimensional echocardiography. A very few cases with ruptured left sinus of Valsalva have been reported. We are reporting a rupture of the left sinus of Valsalva into the main pulmonary artery in a 40-year-old male diagnosed by transthoracic echocardiography.
View Article and Find Full Text PDFIndian J Endocrinol Metab
January 2011
Background And Objectives: Anthropometric variables and their relation to conventional coronary artery disease (CAD) risk factors in railway employees have been inadequately studied in India. This cross-sectional survey was carried out in the Solapur division of the Central railway in the year 2004, to assess the anthropometric variables in railway employees and their relation to conventional CAD risk factors.
Materials And Methods: A total of 995 railway employees, with 872 males and 123 females participated in this cross-sectional study.
Pycnodysostosis is a rare clinical entity, first described in 1962 by Maroteaux and Lamy. The disease has also been named Toulouse-Lautrec syndrome, after the French artist Henri de Toulouse-Lautrec, who (it has been surmised) suffered from the disease. In 1996, the defective gene responsible for Pycnodysostosis was located, offering accurate diagnosis, carrier testing and a more thorough understanding of this disorder.
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