Publications by authors named "Harsha Jujjavarapu"

A toddler presented with hematemesis a few weeks after ingesting a penny. Workup revealed an esophageal lesion communicating with an aortic pseudoaneurysm in the setting of bacteremia. is an oropharyngeal bacteria known to cause fistulas when introduced into tissue planes.

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Article Synopsis
  • - Type I interferons (IFNs) are crucial for fighting viruses and their signaling through the IFN receptor (IFNAR) helps control the responses of the blood-brain barrier (BBB) during viral infections.
  • - The study found that astrocytes, a type of brain cell, play an important role in immune responses at the BBB, particularly in maintaining its permeability and protecting the cerebellum from viral infections.
  • - Mice lacking IFNAR signaling in astrocytes had worse outcomes after being infected with the West Nile virus, indicating that specific signaling pathways in astrocytes help regulate immune responses differently across brain regions.
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Unlabelled: Pattern recognition receptor (PRR) detection of pathogen-associated molecular patterns (PAMPs), such as viral RNA, drives innate immune responses against West Nile virus (WNV), an emerging neurotropic pathogen. Here we demonstrate that WNV PAMPs orchestrate endothelial responses to WNV via competing innate immune cytokine signals at the blood-brain barrier (BBB), a multicellular interface with highly specialized brain endothelial cells that normally prevents pathogen entry. While Th1 cytokines increase the permeability of endothelial barriers, type I interferon (IFN) promoted and stabilized BBB function.

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