Probing polypharmacy, ageing and sex effects on physical function using different tests.

Background: Ageing, sex and polypharmacy affect physical function.

Objectives: This mouse study investigates how ageing, sex and polypharmacy interact and affect grip strength, balance beam and wire hang, correlating and comparing the different test results between and within subgroups.

Methods: Young (2.

Whole-genome resequencing facilitates the development of a 50K single nucleotide polymorphism genotyping array for Scots pine (Pinus sylvestris L.) and its transferability to other pine species.

Scots pine (Pinus sylvestris L.) is one of the most widespread and economically important conifer species in the world. Applications like genomic selection and association studies, which could help accelerate breeding cycles, are challenging in Scots pine because of its large and repetitive genome.

Threatened forests: As the Northern forests suffer from the effects of climate change, genomics has great potential to help them adapt: As the Northern forests suffer from the effects of climate change, genomics has great potential to help them adapt.

Climate change is having dramatic effects on forest health and growth - tree genomics provides tools for understanding and mitigating these effects.

The methylation landscape of giga-genome and the epigenetic timer of age in Chinese pine.

Epigenetics has been revealed to play a crucial role in the long-term memory in plants. However, little is known about whether the epigenetic modifications occur with age progressively in conifers. Here, we present the single-base resolution DNA methylation landscapes of the 25-gigabase Chinese pine (Pinus tabuliformis) genome at different ages.

Spatial Relevance: Teaching History to Medical Students at a Medical Museum in Hong Kong.

This article examines the pedagogical significance of history workshops as part of the mandatory medical curriculum in Hong Kong. At the University of Hong Kong, year one medical students must take a three-hour long history workshop at the Hong Kong Museum of Medical Sciences. We argue that by immersing experiential museum learning into the official medical curriculum, students can grow interest in Hong Kong's local medical history and discover its spatial relevance to their future practice.

Relaying station for empires' outcasts: managing 'lunatics' in pre-World War II Hong Kong.

This article explores how 'lunatics' emerged and how they were managed beyond the capacity of institutionalization in colonial Hong Kong in the second half of the nineteenth century and the first half of the twentieth century. The story contests the conventional historiography about madmen that focuses on institutions. Unlike in Britain or in other East Asian colonial cities, inpatients stayed at the asylum only for very short periods.

Comparing stress and behavioral coping strategies during the early stages of the COVID-19 crisis among domestic and overseas Taiwanese.

This study reported domestic and overseas Taiwanese people's perceived stress levels and examined the mediation effect of their coping strategies during the early stages of the COVID-19 pandemic. We recruited 2727 Taiwanese respondents from the COVIDiSTRESS Global Survey (N = 173,426) between March 30 and May 30, 2020. The self-report questionnaire included a modified 10-item Perceived Stress Scale and a 16-item coping strategy scale.

Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Aging Research.

Aging and multimorbidity are associated with inflammation. Polypharmacy is common in older people with multimorbidity. Given the potential for interactions between polypharmacy and inflammation, the relationship between inflammation and polypharmacy were studied in older adults with multimorbidity and in healthy aging mice.

Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex.

Aging, polypharmacy (concurrent use of ≥ 5 medications), and functional impairment are global healthcare challenges. However, knowledge of the age/sex-specific effects of polypharmacy is limited, particularly on daily physical activities. Using continuous monitoring, we demonstrated how polypharmacy with high Drug Burden Index (DBI-cumulative anticholinergic/sedative exposure) affected behaviors over 23 h in male/female, young/old mice.

Deprescribing in the Older Patient: A Narrative Review of Challenges and Solutions.

Polypharmacy is a major challenge in healthcare for older people, and is associated with increased risks of adverse outcomes, such as delirium, falls, frailty, cognitive impairment and hospitalization. There is significant public and professional interest in the role of deprescribing in reducing medication-related harms in older people. We aim to provide a narrative review of 1) the safety and efficacy of deprescribing interventions, 2) the challenges and solutions of deprescribing research and implementation in clinical practice, and 3) the benefits of using Computerized Clinical Decision Support Systems (CCDSS) and Quality Indicators (QIs) in deprescribing research and practice.

Prevalence Trends in Hearing Aid Use Among US Adults Aged 50 to 69 Years With Hearing Loss-2011 to 2016 vs 1999 to 2004.

This cross-sectional study examines the prevalence of hearing aid use among mid- to late-life older adults aged 50 to 69 years in 2011 to 2016 vs 1999 to 2004 in the US.

Genomic Predictions With Nonadditive Effects Improved Estimates of Additive Effects and Predictions of Total Genetic Values in .

Genomic selection study (GS) focusing on nonadditive genetic effects of dominance and the first order of epistatic effects, in a full-sib family population of 695 Scots pine ( L.) trees, was undertaken for growth and wood quality traits, using 6,344 single nucleotide polymorphism markers (SNPs) generated by genotyping-by-sequencing (GBS). Genomic marker-based relationship matrices offer more effective modeling of nonadditive genetic effects than pedigree-based models, thus increasing the knowledge on the relevance of dominance and epistatic variation in forest tree breeding.