Publications by authors named "Harry Stannard"
Influenza antiviral drugs are important tools in our fight against both annual influenza epidemics and pandemics. Polyphenols are a group of compounds found in plants, some of which have demonstrated promising antiviral activity. Previous in vitro and mouse studies have outlined the anti-influenza virus effectiveness of the polyphenol epigallocatechin-3-gallate (EGCG); however, no study has utilised the ferret model, which is considered the gold-standard for influenza antiviral studies.
View Article and Find Full Text PDFCanine distemper virus (CDV) causes a highly contagious systemic infection in an array of animal species. In this study we report an outbreak of distemper in ferrets in two research facilities in Australia, caused by a novel lineage of CDV. While the CDV strain caused mainly mild symptoms in ferrets, histopathology results presented a typical profile of distemper pathology, with multi-system virus replication.
View Article and Find Full Text PDFArticle Synopsis
- Influenza antivirals, especially in combination, are crucial for managing flu epidemics and potential pandemics, as they can help prevent drug resistance and enhance patient recovery.
- Two immunocompromised patients showed that a combination of antivirals could lead to the emergence of resistant influenza viruses, specifically with mutations NA-H275Y and PA-I38T.
- Although these resistant strains can transmit between hosts, their overall viral fitness is lower than that of the wild type (WT) virus, indicating that large-scale community transmission of these mutants is unlikely.