Future events, early experience, and mental health: clinical assessment using the anticipated life history measure.

This study's goals were (a) to provide convergent validity for the Anticipated Life History measure (ALH), an instrument prompting participants to describe their future life course from their 21st birthday until their death, and (b) to assess the impact of early experience and early memories on the ALH. The ALH narratives were coded for the presence and/or absence of future life events and for five clinical features (Narrative Integrity, Depression, Fantasy Distortion, Impulsivity, and Malevolence) using a detailed scoring manuaL A sample of 285 young adults completed the ALH and a battery of cognitive, mood, and life events measures. The results confirm the utility of this new instrument: Participants whose ALH scored high on the clinical measures also had higher levels of current depression, lower quality-of-life satisfaction, reported more negative early life experiences, and recounted negative early memories.

T cells from newborn humans are fully capable of developing into cytotoxic T lymphocyte effector cells in adoptive hosts.

Background: The finding of reduced incidence of graft-versus-host disease (GVHD) associated with cord blood transplantation, compared to unrelated allogeneic bone marrow, could be related to the lower number of T cells infused in the cord blood (CB) inoculum or it might represent an intrinsic property of CB T cells. We investigated the in vivo function of human cord blood mononuclear cells (CBMC) after their adoptive transfer into lethally irradiated BALB/c radioprotected with severe combined immunodeficiency (SCID) mouse bone marrow.

Methods: The ability of human CBMC to engraft and produce antigen-specific alloreactive cytotoxic T lymphocytes (CTLs) and antibodies was determined by FACS, 51Chromium-release assay, and ELISA.