Letter to the editor regarding "Omega-3 fats in pregnancy: could a targeted approach lead to better metabolic health for children?".

The purpose of our letter to the editor is to offer additional perspective regarding 4 statements that do not fully represent the totality of the available scientific evidence. The 4 statements are as follows: (1) "Multiple studies have shown that n-3 PUFA products frequently have less n-3 PUFA content than labelled"; (2) "Recently, krill oil supplementation was shown to induce insulin resistance, indicating that it is potentially harmful"; (3) "… fish oil products are frequently oxidized at the time of purchase"; and (4) "In rats, supplementation with oxidized fish oil during pregnancy induced persistent maternal insulin resistance and increased neonatal mortality rate." We respectfully request the authors' future publications consider the totality of the available scientific evidence.

Conducting omega-3 clinical trials with cardiovascular outcomes: Proceedings of a workshop held at ISSFAL 2014.

In contrast to earlier long-chain (LC) omega-3 (i.e. EPA and DHA) investigations, some recent studies have not demonstrated significant effects of EPA and DHA on cardiovascular disease (CVD) outcomes.

Considerations for incorporating eicosapentaenoic and docosahexaenoic omega-3 fatty acids into the military food supply chain.

The U.S. military may consider exploring the inclusion of the long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the diets of active duty military personnel.

Nutrient reference values for bioactives: new approaches needed? A conference report.

Nutrients can be classified as either "essential" or "non-essential," the latter are also termed bioactive substances. Whereas the absence of essential nutrients from the diet results in overt deficiency often times with moderate to severe physiological decrements, the absence of bioactive substances from the diet results in suboptimal health. Nutrient reference values are set by Codex Alimentarius and regulatory bodies in many countries, mostly for essential nutrients with recommended daily intakes.

Impact of low v. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease.

The objective of the present study was to determine whether the consumption of ≥ 250 v. < 250 mg of the long-chain n-3 fatty acids (n-3 LCFA) per d is associated with a reduction in the risk of fatal and non-fatal CHD in individuals with no prior history of CHD. A comprehensive and systematic review of the published scientific literature resulted in the identification of eight prospective studies (seven cohorts and one nested case-control study) that met predefined inclusion criteria.

Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides.

The objectives of this review were to determine whether the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent reductions in fasting serum TG levels at the recommended intakes of 200-500 mg/day. The assessment included 15 randomized controlled trials that met pre-defined inclusion and exclusion criteria. Across these 15 studies, the dose-response was modeled using a first-order elimination curve.

Effects of aging on food intake and body composition in rats.

Alterations in the ability to adjust energy intake when optional dietary foods are available may contribute to aging-related changes in body composition. Ingestive behavior, however, has not been extensively studied in aging models. The present research used young, middle-aged and old rats to examine food intake under several different schedules of optional fat availability.