Evaluation of Clinical Performance of Ponto Implantation Using a Minimally Invasive Surgical Technique-A Prospective Multicenter Study.

Objective: To investigate the clinical outcomes of bone-anchored hearing implant surgery using the MONO procedure.

Study Design: Multicenter, multinational, single-arm, prospective trial with a 12-month follow-up.

Setting: Seven European university hospitals from the United Kingdom, Sweden, Denmark, and The Netherlands.

Management of Severe Facial Nerve Cross Stimulation by Cochlear Implant Replacement to Change Pulse Shape and Grounding Configuration: A Case-series.

Objectives: To investigate the combined effect of changing pulse shape and grounding configuration to manage facial nerve stimulation (FNS) in cochlear implant (CI) recipients.

Patients: Three adult CI recipients with severe FNS were offered a replacement implant when standard stimulation strategies and programming adjustments did not resolve symptoms. Our hypothesis was that the facial nerve was less likely to be activated when using anodic pulses with "mixed-mode" intra-cochlear and extra-cochlear current return.

The Epidemiology of Otosclerosis in a British Cohort.

Objective: To analyse the epidemiology of otosclerosis in a British cohort collected between 2011 and 2017.

Design: Retrospective cohort study.

Setting: Five UK ENT Departments.

Evaluating inter-aural hearing preservation in bilateral paediatric cochlear implantation.

Objective: To examine inter-aural hearing preservation results in children undergoing simultaneous bilateral cochlear implantation (CI).

Methods: Retrospective case review in tertiary referral centre. All children undergoing simultaneous bilateral CI between January 2013 and June 2014 (18 months).

Outcomes of Transmastoid Surgery for Superior Semicircular Canal Dehiscence Syndrome.

Objective: To present the management strategy and outcomes for our series of superior semicircular canal dehiscence syndrome (SSCDS) patients.

Study Design: Retrospective cross-sectional study.

Setting: Tertiary referral center.

Cochlear implantation in X-linked deafness - How to manage the surgical challenges.

Objective And Importance: In children with X-linked deafness, cochlear malformations challenge the implant surgeon to avoid electrode insertion into the internal auditory meatus and prevent a continuous cerebrospinal fluid (CSF) leak. We describe our experience of cochlear implantation (CI) in two children with profound hearing loss secondary to X-linked deafness, highlighting safer operative techniques to avoid potential complications.

Clinical Presentation: Descriptive cases of two children with X-linked deafness (patient 1 and patient 2) undergoing CI.

Mutations and altered expression of SERPINF1 in patients with familial otosclerosis.

Otosclerosis is a relatively common heterogenous condition, characterized by abnormal bone remodelling in the otic capsule leading to fixation of the stapedial footplate and an associated conductive hearing loss. Although familial linkage and candidate gene association studies have been performed in recent years, little progress has been made in identifying disease-causing genes. Here, we used whole-exome sequencing in four families exhibiting dominantly inherited otosclerosis to identify 23 candidate variants (reduced to 9 after segregation analysis) for further investigation in a secondary cohort of 84 familial cases.

Cochlear Implant Outcomes in Cochlea Nerve Aplasia and Hypoplasia.

Objective: To assess cochlear implant (CI) outcomes, and factors affecting outcomes, for children with aplasia/ hypoplasia of the cochlea nerve. We also developed a new grading system for the nerves of the internal auditory meatus (IAM) and cochlea nerve classification.

Study Design: Retrospective patient review.

A Comparative Study of Audiologic Outcomes for Two Transcutaneous Bone-Anchored Hearing Devices.

Objective: In 1977, Tjellstrom et al. used the concept of osseointegration and implanted patients with a titanium screw as part of the first bone-anchored hearing solution. Despite good hearing outcomes with the percutaneous device, there has been a drive for the development of transcutaneous bone conduction systems because of soft tissue complications, aesthetics, and loss or failure of the abutment.

Novel surgical management of a laryngeal granular cell tumour.

Granular cell tumour (GCT) is a rare benign tumour occurring, most commonly, in the head and neck. Multiple tumours occur in 5-16% of patients. These tumours are chemo-radio-resistant and have high recurrence rates despite their benign histopathological features.

Large vestibular aqueduct syndrome: Impedance changes over time with different cochlear implant electrode arrays.

Objectives: The aim of this study was to assess if large vestibular aqueduct syndrome (LVAS), with the increase in perilymphatic pressure, affects impedance changes over time with different types of Cochlear(®) implant electrode arrays Contour, Straight, and CI 422. To report speech perception outcomes for these cochlear implant recipients.

Methods: Retrospective case review of impedance levels and categories of auditory performance.

Cochlear re-implant rates in children: 20 years experience in a quaternary paediatric cochlear implant centre.

The aim of this study is to determine the incidence and causes for cochlear explantation/re-implantation in children as a retrospective case review in a Quaternary paediatric Cochlear Implant (CI) Centre. The subjects included in the study were Paediatric CI patients requiring cochlear explantation/re-implantation. Outcome measurements were incidence and aetiology of device explantation/re-implantation.

Resorption of fibula bone following mandibular reconstruction for osteoradionecrosis.

The free fibular flap is commonly used for mandibular reconstruction because of its length, consistent blood supply, and relative ease of harvest. The bone has been shown to maintain mass over time, which confers a potential advantage over other osseous flaps. We know of no published papers on changes in height of fibular bone in patients treated for osteoradionecrosis (ORN).

Improved quality of life in adults undergoing tonsillectomy for recurrent tonsillitis. Is adult tonsillectomy really a low priority treatment?

There is a paucity of studies on patient-reported outcome measures in adult tonsillectomy. Our aim was to add to the body of health-related quality of life (HRQOL) evidence on adult tonsillectomy at a time when this intervention is being branded a low priority treatment in the United Kingdom (UK). We designed a prospective questionnaire study that was carried out in two UK district general hospitals.

Day-case pediatric middle ear surgery: from myringoplasty to bilateral cochlear implantation.

Objective: In the English speaking literature there is very little evidence demonstrating safe and effective tympanomastoid day case surgery in pediatric practice. At a time when there is ongoing pressure for trusts to meet financial government targets and our care provision revolves around a patient centred approach, could otolaryngologists perform more pediatric middle ear surgery on a day case basis? We report our experience with a series of 52 pediatric middle ear day cases.

Method: Prospective study from a London tertiary referral centre of 52 consecutive children undergoing tympanomastoid surgery.

Should all patients referred for magnetic resonance imaging scans of their internal auditory meatus be followed up in ENT clinics?

Magnetic resonance imaging (MRI) is recognised as the "Gold Standard" investigation for symptoms pertaining to the inner ear and detection of retro-cochlear pathology. There is still no accurate clinical predictor for cerebellopontine angle lesions and increasingly more normal scans are being performed. With constantly increasing demands on ENT outpatient clinics, our aim was to investigate whether all patients referred for MRI of their internal auditory meatus (IAM) require follow-up in ENT clinics.

An immunocompetent patient presenting with severe nasal herpes simplex: a case report.

Background: Cutaneous manifestations of common viral pathogens or disease processes more common in immunocompromised individuals need to be considered when assessing patients with unusual clinical presentations. To our knowledge this is the first published case of severe nasal herpes simplex infection in an immunocompetent individual.

Case Presentation: A 27-year-old Burmese woman presented to the Accident and Emergency department with increasing facial pain and fever having sustained local trauma to her nose 7 days prior.

Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain.

The focus of this work was to examine the potential role of p38 mitogen activated protein kinase (p38) in a mouse model of bone cancer (osteosarcoma) pain. To generate osteosarcoma and sham animals, osteosarcoma cells or medium were injected into the medullary canal of the femur. Initially, ipsilateral tactile allodynia was observed in both groups, but by 12 days post-surgery, thresholds in the sham group returned towards baseline while hypersensitivity in the osteosarcoma group lasted throughout the study.