Publications by authors named "Harry Feng"
Article Synopsis
- Mutations in the SETD2 gene are common in renal cell carcinoma (RCC), and a specific single nucleotide polymorphism (SNP), E902Q, was found in some RCC patients as an inherited or tumor-related mutation.
- Researchers used CRISPR to create a similar mutation in the fruit fly gene Set2, discovering that it significantly lowered an important histone modification (H3K36me3) and led to problems with spindle formation during cell division.
- The findings suggest that the SETD2 E902Q SNP not only influences histone methylation and spindle integrity but could also have important implications for understanding and treating RCC clinically.
Background: There is a lack of research on the molecular interaction of the enhancers of rudimentary homolog (ERH) in bladder cancer (BC) cells. This study aimed to determine the interacting proteins of ERH in human T24 cells.
Methods: First, the gene was overexpressed in human T24 cells.
Cancer is a major public health problem worldwide. Studies on oncogenes and tumor-targeted therapies have become an important part of cancer treatment development. In this review, we summarize and systematically introduce the gene enhancer of rudimentary homolog (ERH), which encodes a highly conserved small molecule protein.
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