Publications by authors named "Harrison-Felix C"

Article Synopsis
  • Researchers developed prediction models to estimate the risk of posttraumatic epilepsy (PTE) in individuals who experienced moderate-to-severe traumatic brain injuries (TBI) during a two-year recovery period.
  • The study utilized data from over 6,000 participants in the TBI Model Systems National Database, performing analyses to create models that account for various factors influencing seizure risk post-injury.
  • Key findings indicated that Model 3, which focused on predicting new or recurrent seizures in the second year, had the highest sensitivity (86.63%) and effectiveness, with factors like cranial surgeries and traumatic hemorrhages being significant risk predictors across all models.
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Article Synopsis
  • Memory impairments are a common issue after traumatic brain injury (TBI), and donepezil, a medication that helps with cognitive function, was evaluated for its effectiveness on these memory problems in a clinical trial called MEMRI-TBI-D.
  • The study involved 75 participants with severe memory issues related to TBI, who were split into two groups: one receiving donepezil and the other a placebo over 10 weeks; results showed significant memory improvement in those taking donepezil.
  • While donepezil was effective, it came with some side effects, notably diarrhea and nausea, and had a treatment-emergent adverse event rate of 46%, but overall, it demonstrated a favorable safety profile for treating memory impairments
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Objective: To determine if the interaction of opiate misuse and marijuana use frequency is associated with behavioral health outcomes.

Setting: Community.

Participants: Three thousand seven hundred fifty participants enrolled in the Traumatic Brain Injury Model Systems who completed the Pain Survey and had complete opioid use and marijuana use information.

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Article Synopsis
  • * Participants included 3,804 individuals aged 1 to 30 years post-injury, who completed a Pain Survey about 8 years after their injury.
  • * Results showed that individuals with current chronic pain faced significantly worse psychosocial outcomes, such as higher levels of PTSD, anxiety, and depression, and lower life satisfaction and community participation, compared to those with no pain or resolved past pain.
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Article Synopsis
  • The study assesses chronic pain prevalence in individuals with traumatic brain injury (TBI), finding that about 60% experience chronic pain at some point.
  • It compares three groups: those with current chronic pain, past chronic pain, and no chronic pain, noting that current pain is associated with worse functional outcomes.
  • The results highlight the need for more effective pain management and the inclusion of pain metrics in future research related to TBI.
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Objective: To define and characterize extreme phenotypes based on perceived improvement in pain for persons with chronic pain following traumatic brain injury (TBI).

Setting: Eighteen Traumatic Brain Injury Model System (TBIMS) Centers.

Participants: A total of 1762 TBIMS participants 1 to 30 years post-injury reporting chronic pain at their most recent follow-up interview.

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Objective: To define and characterize extreme phenotypes based on pain interference for persons with chronic pain following traumatic brain injury (TBI).

Setting: Eighteen Traumatic Brain Injury Model System (TBIMS) Centers.

Participants: A total of 1762 TBIMS participants 1 to 30 years post-injury reporting chronic pain at their most recent follow-up interview.

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Objective: To examine the relationship between extreme pain phenotypes (interference and improvement) and psychosocial outcomes among those with chronic pain after traumatic brain injury (TBI).

Setting: Community.

Participants: In total, 1762 TBI Model Systems (TBIMS) participants 1 to 30 years postinjury reporting chronic pain.

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Traumatic brain injury (TBI) is a global health priority, associated with substantial burden. Historically conceptualised as an injury event with finite recovery, TBI is now recognised as a chronic condition that can affect multiple domains of health and function, some of which might deteriorate over time. Many people who have had a TBI remain moderately to severely disabled at 5 years, are rehospitalised up to 10 years post-injury, and have a reduced lifespan relative to the general population.

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Objective: To update the life expectancy estimates according to age, sex, mobility, and feeding skills reported in the 2015 study of Brooks et al. To examine trends in survival over the past decade.

Design: Observational cohort study.

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Objective: To evaluate the efficacy of a novel intervention aimed at enhancing self-advocacy in individuals living with traumatic brain injury (TBI).

Setting: Community.

Participants: Sixty-seven (35 allocated to treatment, 32 to control) community-dwelling adults 9 months or more post-TBI (mean of 8.

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Objective: This study compared traumatic brain injury (TBI) outcomes from 2 cohorts: the National Institute on Disability, Independent Living, and Rehabilitation Research Traumatic Brain Injury Model Systems (TBIMS) in the United States and Longitudinal Head Injury Outcome Study conducted in Victoria, Australia, by the Monash Epworth Rehabilitation Research Centre (MERRC).

Design: Cohort study with 1- and 2-year follow-up.

Setting: Acute trauma care and inpatient rehabilitation with follow-up.

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Studies have shown reduced life expectancy following moderate-severe traumatic brain injury (TBI) with death from unintentional poisoning (UP) being 11 times higher following TBI than in the general population. The characteristics of those who die of unintentional poisoning are compared with the characteristics of those who die of other causes (OC) in a retrospective cohort who received inpatient rehabilitation following TBI and enrolled in the TBI Model Systems National Database between 1989 and 2017 ( = 15,835 cases with 2,238 deaths recorded). Seventy-eight cases (3.

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Objective: To evaluate the efficacy of a novel intervention facilitating volunteer activity to improve well-being in individuals with traumatic brain injury (TBI).

Design: Randomized two-arm controlled trial, with a wait-list control condition (ClinicalTrials.gov NCT#01728350).

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: Volunteering has been found to improve life satisfaction and participation in the general population, but its impact has not been thoroughly studied among those with traumatic brain injury (TBI). It is important to investigate whether volunteering is helpful in addressing participation and life satisfaction to inform future treatment.: To characterize those who volunteer after moderate-severe TBI and to investigate the association of volunteering with participation and life satisfaction after TBI.

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Objective: To evaluate the efficacy of an in-home 12-week physical therapy (PT) intervention that utilized a virtual reality (VR) gaming system to improve balance in individuals with traumatic brain injury (TBI).

Setting: Home-based exercise program (HEP).

Participants: Individuals (N=63; traditional HEP n=32; VR n=31) at least 1 year post-TBI, ambulating independently within the home, not currently receiving PT services.

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Objective: To assess associations among commonly used self-report and clinical measures of balance in chronic TBI.

Design: Cross-sectional analysis of balance in a convenience sample of individuals at least one year post TBI.

Main Outcome Measures: Activities-Specific Balance Confidence Scale (ABC) (self-reported balance impairment), Community Balance and Mobility Scale (CB&M) (clinical measure validated in TBI), and Balance Evaluation Systems Test (BESTest) (clinical measure not validated in TBI).

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The Traumatic Brain Injury Model Systems Center (TBIMSC) program was established by the National Institute on Disability, Independent Living, and Rehabilitation Research in 1987, with the goal of conducting research to improve the care and outcomes for individuals with moderate-to-severe traumatic brain injury (TBI). This article provides an update on TBIMSC research program activities since 2010 when a similar article was published. It includes (1) discussion of TBIMSC program management and infrastructure; (2) detail on the management, data quality, access, use, and knowledge translation of the TBIMSC National Database, with more than 16 000 participants with follow-up out to 25 years postinjury to date; (3) an overview of the TBIMSC site-specific studies and collaborative module research; (4) highlights of several collaborative initiatives between the TBIMSCs and other federal, advocacy, and research stakeholders; (5) an overview of the vast knowledge translation occurring through the TBIMSC program; and (6) discussion of issues that impact on the data collection methods for and contents of the TBIMSC National Database.

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Objective: To build decision tree prediction models for long-term employment outcomes of individuals after moderate to severe closed traumatic brain injury (TBI) and assess model accuracy in an independent sample.

Setting: TBI Model Systems Centers.

Participants: TBI Model Systems National Database participants injured between January 1997 and January 2017 with moderate to severe closed TBI.

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Objective: To evaluate the effectiveness of a replicable group treatment program for improving social competence after traumatic brain injury (TBI).

Design: Multicenter randomized controlled trial comparing 2 methods of conducting a social competency skills program, an interactive group format versus a classroom lecture.

Setting: Community and veteran rehabilitation centers.

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Background: Well-being and quality of life issues remain a long-term problem for many individuals with traumatic brain injury (TBI). Meaningful activity is key to developing life satisfaction and a sense of contribution to society, yet individuals with TBI are often unable to return to competitive employment.

Objective: To describe the self-reported psychological well-being of a cohort of unemployed individuals living in the community at least 1 year post TBI with low life satisfaction.

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For patients surviving serious traumatic brain injury (TBI), families and other stakeholders often desire information on long-term functional prognosis, but accurate and easy-to-use clinical tools are lacking. We aimed to build utilitarian decision trees from commonly collected clinical variables to predict Glasgow Outcome Scale (GOS) functional levels at 1, 2, and 5 years after moderate-to-severe closed TBI. Flexible classification tree statistical modeling was used on prospectively collected data from the TBI-Model Systems (TBIMS) inception cohort study.

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Objective: To test efficacy of 8-session, 1:1 treatment, anger self-management training (ASMT), for chronic moderate to severe traumatic brain injury (TBI).

Setting: Three US outpatient treatment facilities.

Participants: Ninety people with TBI and elevated self-reported anger; 76 significant others (SOs) provided collateral data.

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