Multi-omic analysis of the ciliogenic transcription factor reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neurons.

Heterozygous loss-of-function (LoF) variants in a transcription factor known to play key roles in ciliogenesis, result in autism spectrum disorder (ASD) and neurodevelopmental delay. RFX binding motifs are also enriched upstream of genes found to be commonly dysregulated in transcriptomic analyses of brain tissue from individuals with idiopathic ASD. Still, the precise functions of in the human brain is unknown.

Microbial community succession on submerged vertebrate carcasses in a tidal river habitat: Implications for aquatic forensic investigations.

Death investigations in aquatic ecosystems are challenging due to abiotic and biotic factors that may influence the estimation of a postmortem submersion interval (PMSI). In this study, we examined bacterial changes throughout the decomposition process on porcine carcasses submerged in a tidal-influenced river and identified predictors of epinecrotic community succession. Fetal porcine (Sus scrofa) carcasses (N = 6) were submerged with epinecrotic samples collected every 3 days (6 collections) over a period of 19 days (~7415 accumulated degree hours (ADH)).

Atmospheric CO(2) column measurements in cloudy conditions using intensity-modulated continuous-wave lidar at 1.57 micron.

This study evaluates the capability of atmospheric CO column measurements under cloudy conditions using an airborne intensity-modulated continuous-wave integrated-path-differential-absorption lidar operating in the 1.57-μm CO absorption band. The atmospheric CO column amounts from the aircraft to the tops of optically thick cumulus clouds and to the surface in the presence of optically thin clouds are retrieved from lidar data obtained during the summer 2011 and spring 2013 flight campaigns, respectively.

Binary phase shift keying on orthogonal carriers for multi-channel CO2 absorption measurements in the presence of thin clouds.

A new modulation technique for Continuous Wave (CW) Lidar is presented based on Binary Phase Shift Keying (BPSK) using orthogonal carriers closely spaced in frequency, modulated by Maximum Length (ML) sequences, which have a theoretical autocorrelation function with no sidelobes. This makes it possible to conduct multi-channel atmospheric differential absorption measurements in the presence of thin clouds without the need for further processing to remove errors caused by sidelobe interference while sharing the same modulation bandwidth. Flight tests were performed and data were collected using both BPSK and linear swept frequency modulation.

Super-resolution technique for CW lidar using Fourier transform reordering and Richardson-Lucy deconvolution.

An interpolation method is described for range measurements of high precision altimetry with repeating intensity modulated continuous wave (IM-CW) lidar waveforms using binary phase shift keying (BPSK), where the range profile is determined by means of a cross-correlation between the digital form of the transmitted signal and the digitized return signal collected by the lidar receiver. This method uses reordering of the array elements in the frequency domain to convert a repeating synthetic pulse signal to single highly interpolated pulse. This is then enhanced further using Richardson-Lucy deconvolution to greatly enhance the resolution of the pulse.

High-resolution CW lidar altimetry using repeating intensity-modulated waveforms and Fourier transform reordering.

An interpolation method is described for range measurements of high precision and altimetry using repeating intensity-modulated continuous wave (IM-CW) lidar waveforms, where the range is determined by means of a cross-correlation between the digital form of the transmitted signal and the digitized return signal collected by the lidar receiver. This method uses reordering of the array elements in the frequency domain to convert a repeating synthetic pulse signal to single highly interpolated pulse. The computation of this processing is marginally greater than the correlation itself, as it only involves reordering of the correlation in the frequency domain, which makes it possible to implement this in a real time application.

Atmospheric CO2 column measurements with an airborne intensity-modulated continuous wave 1.57 μm fiber laser lidar.

The 2007 National Research Council (NRC) Decadal Survey on Earth Science and Applications from Space recommended Active Sensing of CO(2) Emissions over Nights, Days, and Seasons (ASCENDS) as a midterm, Tier II, NASA space mission. ITT Exelis, formerly ITT Corp., and NASA Langley Research Center have been working together since 2004 to develop and demonstrate a prototype laser absorption spectrometer for making high-precision, column CO(2) mixing ratio measurements needed for the ASCENDS mission.