Publications by authors named "Harrison L"

Background: To minimise the referral gap to pain psychology, the purpose of this study was to describe clinician-perceived patient suitability for pain psychology referral, develop a referral plan and outline essential elements of a referral conversation via a modified Delphi approach with multidisciplinary paediatric pain providers.

Methods: We employed a three-round modified Delphi approach consulting multidisciplinary paediatric pain providers (n=18) including physicians, psychologists, physical therapists, occupational therapists and nurse practitioners (PT, OT, NP). Based on the responses to an online survey (Round 1), initial statements regarding the pain psychology referral process were developed.

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Introduction The neonatal period is the most vulnerable time in a child's life, contributing to almost half of all deaths in children under 5 years. Many of these deaths are preventable and are mainly caused by preterm birth, birth asphyxia, or serious infections. Over the past decade, the evidence base for interventions to prevent and manage these causes of neonatal mortality and morbidity in low- and middle-income countries (LMICs) has expanded significantly.

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Pathogen genomic surveillance in healthcare has the potential to enhance patient safety by detecting outbreaks earlier, thereby reducing morbidity and mortality. Despite benefits, there are barriers to adoption, including cost, expertise, and lack of standardized methodologies and incentives. This commentary advocates for 1) investment from healthcare payors, public health, and regulatory bodies and 2) additional research on genomic surveillance for improving patient outcomes and reducing infections.

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Introduction: The potential impact of an in-development 24-valent pneumococcal conjugate vaccine (PCV24) compared to currently recommended vaccines in older adults is unclear. Similar to most currently available PCVs, PCV24's formulation is based on childhood pneumococcal disease epidemiology. Decision analysis techniques were used to estimate PCV24 cost-effectiveness and public health effects in US older adults.

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Introduction: To describe recent evidence regarding the most effective neonatal resuscitation training program and scale-up of these programs in low- and middle-income countries (LMICs), which has contributed to the upcoming Lancet Global Newborn Care Series 2025, and forms part of a supplement describing an extensive synthesis on effective newborn interventions in LMICs.

Methods: We included relevant studies from Medline, Embase, CINAHL, Cochrane CENTRAL and Global Index Medicus databases on the effectiveness and scale-up of Neonatal Resuscitation Training Programs (NRTP), with searches run August 2022. Data extraction and quality assessments were completed independently and in duplicate.

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We report 2 outbreaks comprising a cluster of 18 group A Streptococcal infections across 2 nursing facilities. Point prevalence surveillance testing identified 8 of 18 cases, and whole genome sequencing validated transmission pathways. Infection prevention interventions at the facility level comprised symptomatic and asymptomatic carriage-based case finding, transmission-based precautions, and treatment to eradicate colonization.

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Introduction: Small vulnerable newborns (SVNs) are at an increased risk of early death and other morbidities. Essential interventions provided to SVN, and other high-risk newborns have been proven critical in improving their outcomes. We aimed to provide an update on the effectiveness and safety of these interventions in low- and middle-income countries (LMICs).

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Introduction: Neonatal respiratory conditions are leading causes of mortality and morbidity during the neonatal period. This review evaluated 11 management interventions for respiratory distress syndrome (RDS), apnoea of prematurity (AOP), meconium aspiration syndrome (MAS), transient tachypnea of the newborn (TTN), as well as bronchopulmonary dysplasia (BPD) as a potential complication from respiratory care in low- and middle-income countries (LMICs).

Methods: Two different methodological approaches were completed: (1) updating outdated reviews and pooling all LMIC studies and (2) re-analysis of LMIC studies from up-to-date reviews.

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To estimate the effect of influenza vaccination disparities. We compared symptomatic influenza cases between Black and White races in 2 scenarios: (1) race- and age-specific vaccination coverage and (2) equal vaccination coverage. We also compared differences in household composition between races.

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Introduction: Effective post-resuscitation care is crucial for improving outcomes in neonates post-asphyxia. This review aimed to provide a comprehensive overview of post-asphyxial aftercare strategies and forms part of a supplement describing an extensive synthesis of effective newborn interventions in low- and middle-income countries (LMICs).

Methods: Evidence was generated by performing de novo reviews, updates to reviews via systematic searches, and reanalyses of studies conducted in LMICs from existing reviews.

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Tropical Animal Health and Production is a journal founded 55 years ago. It is dedicated to the publication of results of original research, investigation, and observation in all fields of animal health, welfare and production which may lead to improved health and productivity of livestock and better utilization of animal resources in tropical, subtropical and similar environments. Research is in strong alignment with the United Nations' Sustainable Development Goals, particularly No Poverty, Zero Hunger, and Good Health and Well-being.

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Introduction: We present a robust and up-to-date synthesis of evidence on the effectiveness of interventions to prevent and treat newborn infections in low- and middle-income countries (LMICs). Newborn infection prevention interventions included strategies to reduce antimicrobial resistance (AMR), prevention of healthcare-associated infections (HAIs), clean birth kits (CBKs), chlorhexidine cleansing, topical emollients, and probiotic and synbiotic supplementation. Interventions to treat suspected neonatal infections included prophylactic systemic antifungal agents and community-based antibiotic delivery for possible serious bacterial infections (PSBIs).

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Background: Several interventions provided to newborns at birth or within 24 h after birth have been proven critical in improving neonatal survival and other birth outcomes. We aimed to provide an update on the effectiveness and safety of these interventions in low- and middle-income countries (LMICs).

Summary: Following a comprehensive scoping of the literature, we updated or re-analyzed the LMIC-specific evidence for included topics.

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Article Synopsis
  • The study aimed to analyze the treatment patterns and outcomes of pneumatic retinopexy (PnR) in patients with rhegmatogenous retinal detachments (RRD) utilizing data from the IRIS® Registry over the years 2013-2022.
  • Results showed that the overall single-operation success (SOS) rate for PnR was 59.82%, with specific complications noted, such as vitreous hemorrhage in 9.1% of cases, and poorer visual acuity outcomes for eyes that failed the procedure.
  • The findings concluded that, while PnR is widely used, its SOS rate is lower than previously reported, and phakic eyes had better outcomes compared to pseud
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In Western Europe, many countries have robust and well-established surveillance systems and case reporting mechanisms. IMD incidence across Western Europe is low with a predominance of meningococcal serogroup B (MenB). Case confirmation and antimicrobial susceptibility testing is often standardised in this region, with many countries also having robust vaccination programmes in place.

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It is increasingly clear that social environments have profound impacts on the life histories of 'non-social' animals. However, it is not yet well known how species with varying degrees of sociality respond to different social contexts and whether such effects are sex-specific. To survey the extent to which social environments specifically affect lifespan and ageing in non-social species, we performed a systematic literature review, focusing on invertebrates but excluding eusocial insects.

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Background: There is consensus on the need and ability to address firearm injury risk in healthcare settings; however, the lack of education for healthcare professionals hinders the implementation of evidence-based firearm injury and mortality prevention strategies. The objectives of this study are to develop, disseminate and evaluate education for team members to facilitate implementation in emergency departments METHOD: Two-tiered education was developed in partnership with stakeholders and disseminated to the healthcare team, covering evidence-based screening and interventions for firearm access and violence risk. The implementation, development and dissemination strategies followed the framework used for systemwide Screening, Brief Intervention and Referral to Treatment implementation for substance use.

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  • The study explores how caregivers of children with cancer in Guatemala City understand illness through Explanatory Models (EMs) during clinical interactions at Unidad Nacional de Oncología Pediátrica (UNOP).
  • It involved analyzing audio recordings and interviews from caregivers to identify how the EM components—cause, occurrence, pathophysiology, course of sickness, and treatment—were discussed in the diagnostic process.
  • The findings revealed that while clinicians often initiated EM discussions, caregivers engaged with most components, particularly focusing on personal illness experiences rather than technical aspects like pathophysiology, highlighting the importance of culturally-competent communication in pediatric oncology care.
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  • Current outbreak detection methods in hospitals are inadequate on their own; a new program called the Enhanced Detection System for Healthcare-associated Transmission (EDS-HAT) uses real-time genomic surveillance to identify outbreaks.
  • The study, conducted at UPMC Presbyterian Hospital from November 2021 to October 2023, involved weekly whole genome sequencing of bacterial isolates, leading to the identification of 172 outbreaks and successful intervention strategies that prevented further transmission in over 95% of cases.
  • Results revealed significant benefits: 62 infections were avoided, translating to over $1 million in gross savings and a net savings of nearly $700,000, showing that integrating genomic surveillance can greatly enhance infection control and patient safety.
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Germline genomic sequencing is increasingly integrated into pediatric cancer care, with pathogenic cancer-predisposing variants identified among 5-18% of affected children and variants of uncertain significance (VUS) in up to 70%. Given the potential medical implications for children and their families, parents' psychosocial responses to learning results are important to understand. Parents of children with cancer who learned their children's germline pathogenic or VUS results following paired tumor and germline genomic sequencing described their cognitive and affective responses to results in an open-ended write-in question after disclosure (M = 10 months post-disclosure; range = 1-28).

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Article Synopsis
  • A study looked at how safe and helpful it is to use nose sprays of certain medicines, fentanyl and midazolam, for kids in hospitals.
  • The study found that most kids received midazolam, and these medicines were often used when kids had to go through procedures like getting an IV or a lumbar puncture.
  • No serious side effects were reported, but the researchers say more studies should be done before using these medicines more widely in hospitals.
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Parents and carers face many challenges following their child's autism diagnosis. They often look for information, and social and emotional support. There has been relatively little research into how best to provide this support and this means that there is no evidence to guide the delivery of services.

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