Improved exercise capacity in cyclophilin-D knockout mice associated with enhanced oxygen utilization efficiency and augmented glucose uptake AMPK-TBC1D1 signaling nexus.

We previously reported in HEK 293T cells that silencing the mitochondrial peptidyl prolyl isomerase cyclophilin-D (Cyp-D) reduces o. We now report that Cyp-D ablation using constitutive Cyp-D knockout (KO) mice also reduces o both at rest (∼15%) and during treadmill exercise (∼12%). Yet, despite o reduction, these Cyp-D KO mice ran longer (1071 ± 77 785 ± 79 m; = 0.