Publications by authors named "Harriet Vreugdenhil"
Adoption of C-reactive protein point-of-care tests for the management of acute childhood infections in primary care in the Netherlands and England: a comparative health systems analysis.
BMC Health Serv Res
February 2023
Article Synopsis
- The study investigates the factors influencing the adoption of CRP point of care (POC) tests in the Netherlands and England, noting significant differences in their availability despite similar healthcare systems.
- Researchers used qualitative case studies, analyzing documents and conducting interviews with stakeholders, guided by the NASSS framework.
- Results indicate that successful adoption in the Netherlands was driven by strong advocacy, evidence generation, support from health services, and mandatory reimbursement, while England faced challenges due to funding constraints and alternative priorities in healthcare.
The authors have previously shown that mechanical ventilation can result in increased pulmonary inflammation and suppressed peripheral leukocyte function. In the present study the effect of surfactant therapy on pulmonary inflammation and peripheral immune function in ventilated surfactant-deficient rats was assessed. Surfactant deficiency was induced by repeated lung lavage, treated rats with surfactant or left them untreated, and ventilated the rats during 2 hours.
View Article and Find Full Text PDFObjective: To investigate the effect of mechanical ventilation with no PEEP (ZEEP) and 4 cmH(2)O PEEP on heat shock protein 70 (HSP70) and pulmonary inflammatory cytokine expression in a model of lipopolysaccharide (LPS) induced lung inflammation.
Design And Setting: Prospective, randomized, experimental animal study.
Subjects And Interventions: We challenged 42 male Sprague-Dawley rats intratracheally with LPS.
Objective: This study was undertaken to examine the hypothesis that mechanical ventilation in association with anesthesia would alter the cytokine profile in infants without preexisting lung pathology.
Design And Setting: Prospective observational study in pediatric intensive care unit in a university hospital.
Patients: Twelve infants who were subjected to an uncomplicated diagnostic cardiac catheterization procedure were studied.