Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotheray for methamphetamine use disorder (the KAPPA trial).

Introduction: Methamphetamine use disorder is a significant public health concern. No pharmacological treatment options currently exist for methamphetamine use disorder, and psychotherapy is only moderately effective. Preliminary evidence suggests that ketamine-assisted psychotherapy produces sustained improvements in substance use and mental health symptomatology.