Sorafenib tosylate-loaded nanosuspension: preparation, optimization, and cytotoxicity study against human HepG2 carcinoma cells.

This study aimed to optimize nanosuspension of sorafenib tosylate (an anticancer hydrophobic drug molecule) using a central composite design. Nanosuspension was prepared using a nanoprecipitation-ultrasonication approach. FTIR and DSC analyses demonstrated that the drug and excipients were physicochemically compatible.

Recent Patents and Potential Applications of Homogenisation Techniques in Drug Delivery Systems.

Background: The term homogenise means "to force or provide coalesce". Homogenisation is a process to attain homogenous particle size. The objective of the homogenisation process is to use fluid force to split the fragments or tiny particles contained in the fluids into very small dimensions and form a sustainable dispersion suitable for further production.